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- W2049490787 abstract "Candida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans. In instances where host debilitation occurs, Candida can cause a range of clinical infections, and whilst these are primarily superficial, effecting mucosal membranes, systemic infections can develop in severely immunocompromised individuals. The mechanism of host immunity during commensal carriage of C. albicans has been intensively studied. In this paper, we present the most recent information concerning host recognition of C. albicans leading to cytokine production and the subsequent T-cell responses generated in response to C. albicans . Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida . T-cells are considered crucial in the regulation of immunity and inflammation. In this regard, the role of Th1/2, helper cells, together with the recently identified Th17 and Treg cells in candidosis will be discussed. Understanding the detailed mechanisms that underlie host immunity to Candida not only will be of benefit in terms of the infections caused by this organism but could also be exploited in the development of therapeutic interventions for other diseases." @default.
- W2049490787 created "2016-06-24" @default.
- W2049490787 creator A5018295349 @default.
- W2049490787 creator A5021395372 @default.
- W2049490787 creator A5026562442 @default.
- W2049490787 creator A5069907035 @default.
- W2049490787 date "2011-01-01" @default.
- W2049490787 modified "2023-10-11" @default.
- W2049490787 title "The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis" @default.
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- W2049490787 doi "https://doi.org/10.1155/2011/697340" @default.
- W2049490787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2963117" @default.
- W2049490787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20981280" @default.
- W2049490787 hasPublicationYear "2011" @default.
- W2049490787 type Work @default.