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- W2049498272 abstract "Undifferentiated pleomorphic sarcoma (UPS) is a common soft tissue sarcoma with a high propensity for metastasis. Our aim is to develop and validate a set of miRNA expression signature that can predict distant metastasis-free survival (DMFS). One hundred eighteen untreated and pathologically reviewed UPS fresh frozen tissue samples were obtained, which served as the training (42), and validation (68) cohorts. The clinical characteristics between these two UPS cohorts were similar except for an older age (p = 0.04) and a shorter median follow-up time (123 vs. 28 months) for the latter group. Global micro-RNA (miRNA) profiling was first conducted on the training cohort using an RT-PCR device. Candidate miRNAs which associated with DMFS were then measured in the validation cohort using single well quantitative RT-PCR. Cox multivariate modeling was used to derive a signature that was tested on the validation cohort using Kaplan-Meier. Global miRNA profiling identified a candidate set of 27 miRNAs which were associated with DMFS and other clinical outcomes. Following Cox multivariate regression modeling, a 6-miRNA set was derived from the original 27 miRNAs. Using this 6-miRNA signature, patients from the validation set were indeed successfully categorized into “High” and “Low” risk groups for DMFS (HR:2.2, CI:1.0-4.9; p = 0.05). Using Gene Ontology Pathway analyses, these six miRNAs are known to modulate cellular senescence, DNA repair, angiogenesis, epithelial-mesenchymal transition and metastasis. A prognostic miRNA signature consisting of six miRNAs has been successfully developed and validated for UPS. This signature could help identify patients at “High” risk for distant metastasis, who might benefit from more aggressive systemic therapies. Further, examination of the biological roles of these miRNAs in sarcoma could lead to the identification of novel therapeutic targets which can impact on survival for future patients with UPS." @default.
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- W2049498272 date "2012-11-01" @default.
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- W2049498272 title "A Potential Prognostic MicroRNA Signature for Distant Metastasis in Soft-tissue Sarcomas" @default.
- W2049498272 doi "https://doi.org/10.1016/j.ijrobp.2012.07.066" @default.
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