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• W2049503095 startingPage "417" @default.
• W2049503095 abstract "The aim of the present study was to assess in the rat the pharmacological, biochemical and molecular (including in situ hybridization) consequences in the striatum of a prolonged (50 days) treatment with dizocilpine maleate (MK-801), an N-methyl-D-aspartate (NMDA) antagonist. We observed a sensitization-like effect characterized by a behavioural hyperresponsiveness to an acute injection of haloperidol (0.25 mg/kg), a dopaminergic antagonist. In rats chronically treated with MK-801, this hyperresponsiveness was associated with an increased D2 receptor (D2R) density in the striatum. At the transcriptional level, the D2R mRNA was also enhanced in the striatum. Quantitative in situ hybridization studies revealed that the number of neurons expressing the D2R mRNA was significantly enhanced in treated rats, whereas the mean amount of message per cell was unchanged. These changes could represent the neurobiological substrate of the observed sensitization. These results suggest that the D2R gene is under glutamate control via NMDA receptor in striatal neurons." @default.
• W2049503095 created "2016-06-24" @default.
• W2049503095 creator A5000028240 @default.
• W2049503095 creator A5044547380 @default.
• W2049503095 date "1997-01-01" @default.
• W2049503095 modified "2023-10-16" @default.
• W2049503095 title "Sensitization of the striatal dopaminergic system induced by chronic administration of a glutamate antagonist in the rat" @default.
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• W2049503095 cites W1972579416 @default.
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• W2049503095 doi "https://doi.org/10.1016/s0149-7634(96)00041-3" @default.
• W2049503095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9195599" @default.
• W2049503095 hasPublicationYear "1997" @default.
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