FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049509954> ?p ?o ?g. }

• W2049509954 endingPage "1262" @default.
• W2049509954 startingPage "1255" @default.
• W2049509954 abstract "Aims/hypothesis. Semicarbazide-sensitive amine oxidase has been recognised to be a potential risk factor in vascular disorders associated with diabetic complications and to be related to mortality in patients suffering from heart disease. This enzyme, associated with the vascular system, catalyses the deamination of methylamine and aminoacetone, and also acts as an adhesion molecule related to leucocyte trafficking and inflammation. The deaminated products include the toxic aldehydes, formaldehyde and methylglyoxal, respectively, hydrogen peroxide and ammonia. Materials and methods. In this study, the KKAy mouse, a strain possessing features closely resembling those of Type II (non-insulin-dependent) diabetes mellitus has been used to substantiate the hypothesis. Vascular lesions were induced via chronic feeding of a high cholesterol diet. Results. Both MDL-72974A, a selective mechanism-based semicarbazide-sensitive amine oxidase inhibitor and aminoguanidine effectively inhibited aorta semicarbazide-sensitive amine oxidase activity, and caused a substantial increase in urinary methylamine, and a decrease in formaldehyde and methylgloxal levels. Inhibition of semicarbazide-sensitive amine oxidase also reduced oxidative stress, as shown by a reduction of malondialdehyde excretion. Both MDL-72974A and aminoguanidine reduced albuminuria, proteinuria and the number of atherosclerotic lesions in animals fed with a cholesterol diet over a period of treatment for 16 weeks. Conclusion/interpretation. Increased semicarbazide-sensitive amine oxidase–mediated deamination could be involved in the cascade of atherogenesis related to diabetic complications." @default.
• W2049509954 created "2016-06-24" @default.
• W2049509954 creator A5004307414 @default.
• W2049509954 creator A5013301518 @default.
• W2049509954 creator A5046036216 @default.
• W2049509954 creator A5069136939 @default.
• W2049509954 creator A5078187507 @default.
• W2049509954 date "2002-08-08" @default.
• W2049509954 modified "2023-10-12" @default.
• W2049509954 title "Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet" @default.
• W2049509954 cites W1522796118 @default.
• W2049509954 cites W1551586253 @default.
• W2049509954 cites W1565651681 @default.
• W2049509954 cites W1840260164 @default.
• W2049509954 cites W1845662559 @default.
• W2049509954 cites W1971225531 @default.
• W2049509954 cites W1975061946 @default.
• W2049509954 cites W1979064868 @default.
• W2049509954 cites W1987290579 @default.
• W2049509954 cites W2008941833 @default.
• W2049509954 cites W2020868635 @default.
• W2049509954 cites W2022183562 @default.
• W2049509954 cites W2024907296 @default.
• W2049509954 cites W2026703782 @default.
• W2049509954 cites W2032055976 @default.
• W2049509954 cites W2032272012 @default.
• W2049509954 cites W2051759603 @default.
• W2049509954 cites W2055589739 @default.
• W2049509954 cites W2060230815 @default.
• W2049509954 cites W2077462721 @default.
• W2049509954 cites W2078187032 @default.
• W2049509954 cites W2088189909 @default.
• W2049509954 cites W2091039013 @default.
• W2049509954 cites W2100250312 @default.
• W2049509954 cites W2122934303 @default.
• W2049509954 cites W2168621707 @default.
• W2049509954 cites W2171782655 @default.
• W2049509954 cites W2395293084 @default.
• W2049509954 cites W2398277241 @default.
• W2049509954 cites W81056946 @default.
• W2049509954 cites W2004252049 @default.
• W2049509954 doi "https://doi.org/10.1007/s00125-002-0903-9" @default.
• W2049509954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12242458" @default.
• W2049509954 hasPublicationYear "2002" @default.
• W2049509954 type Work @default.
• W2049509954 sameAs 2049509954 @default.
• W2049509954 citedByCount "37" @default.
• W2049509954 countsByYear W20495099542013 @default.
• W2049509954 countsByYear W20495099542016 @default.
• W2049509954 countsByYear W20495099542017 @default.
• W2049509954 countsByYear W20495099542019 @default.
• W2049509954 countsByYear W20495099542020 @default.
• W2049509954 countsByYear W20495099542021 @default.
• W2049509954 countsByYear W20495099542022 @default.
• W2049509954 countsByYear W20495099542023 @default.
• W2049509954 crossrefType "journal-article" @default.
• W2049509954 hasAuthorship W2049509954A5004307414 @default.
• W2049509954 hasAuthorship W2049509954A5013301518 @default.
• W2049509954 hasAuthorship W2049509954A5046036216 @default.
• W2049509954 hasAuthorship W2049509954A5069136939 @default.
• W2049509954 hasAuthorship W2049509954A5078187507 @default.
• W2049509954 hasBestOaLocation W20495099541 @default.
• W2049509954 hasConcept C117001961 @default.
• W2049509954 hasConcept C126322002 @default.
• W2049509954 hasConcept C134018914 @default.
• W2049509954 hasConcept C145782189 @default.
• W2049509954 hasConcept C178790620 @default.
• W2049509954 hasConcept C181199279 @default.
• W2049509954 hasConcept C185592680 @default.
• W2049509954 hasConcept C197974221 @default.
• W2049509954 hasConcept C2778592357 @default.
• W2049509954 hasConcept C2778627024 @default.
• W2049509954 hasConcept C2778969155 @default.
• W2049509954 hasConcept C2779053737 @default.
• W2049509954 hasConcept C2779183435 @default.
• W2049509954 hasConcept C55493867 @default.
• W2049509954 hasConcept C71924100 @default.
• W2049509954 hasConceptScore W2049509954C117001961 @default.
• W2049509954 hasConceptScore W2049509954C126322002 @default.
• W2049509954 hasConceptScore W2049509954C134018914 @default.
• W2049509954 hasConceptScore W2049509954C145782189 @default.
• W2049509954 hasConceptScore W2049509954C178790620 @default.
• W2049509954 hasConceptScore W2049509954C181199279 @default.
• W2049509954 hasConceptScore W2049509954C185592680 @default.
• W2049509954 hasConceptScore W2049509954C197974221 @default.
• W2049509954 hasConceptScore W2049509954C2778592357 @default.
• W2049509954 hasConceptScore W2049509954C2778627024 @default.
• W2049509954 hasConceptScore W2049509954C2778969155 @default.
• W2049509954 hasConceptScore W2049509954C2779053737 @default.
• W2049509954 hasConceptScore W2049509954C2779183435 @default.
• W2049509954 hasConceptScore W2049509954C55493867 @default.
• W2049509954 hasConceptScore W2049509954C71924100 @default.
• W2049509954 hasIssue "9" @default.
• W2049509954 hasLocation W20495099541 @default.
• W2049509954 hasLocation W20495099542 @default.
• W2049509954 hasOpenAccess W2049509954 @default.
• W2049509954 hasPrimaryLocation W20495099541 @default.
• W2049509954 hasRelatedWork W1970037458 @default.

• next