FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049514044> ?p ?o ?g. }

• W2049514044 endingPage "219" @default.
• W2049514044 startingPage "211" @default.
• W2049514044 abstract "Changes in levels of adenosine, inosine, hypoxanthine and ATP during complete ischemia after decapitation were determined in various areas of the guinea pig and rat brain using an HPLC method. These results were compared with levels in brains fixed by microwave irradiation. The levels of adenosine during 60 min of complete ischemia were extremely high and unevenly distributed while levels in the microwaved brains were very low and evenly distributed. The ratios of inosine plus hypoxanthine levels to adenosine which indicate the rate of metabolic degradation from adenosine into inosine and hypoxanthine, were also unevenly distributed during complete ischemia in the cerebellum, superior colliculus, cerebral cortex and hippocampus of the guinea pig and rat, and the highest ratio was observed in the cerebellum of the guinea pig and the superior colliculus of the rat. The activities of adenosine deaminase (ADA), one of the enzymes involved in adenosine metabolism, were measured in the four regions of the guinea pig. The ADA activities were unevenly distributed and the highest ADA activity was found in the cerebellum. These regional differences in ADA activities are in good agreement with the regional differences in the ratio of inosine plus hypoxanthine levels to adenosine during complete ischemia. Furthermore, the administration of EHNA [erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride] (10 mg/kg, i.p.), an ADA inhibitor, caused a significant increase of adenosine and decrease of inosine formation in all four regions and a drastic effect on the cerebellum with high ADA activity compared with the other regions in the guinea pig brain. These results indicate that the changes in concentrations of adenosine and its metabolites (inosine and hypoxanthine) during complete ischemia depend on ADA activity in each brain region." @default.
• W2049514044 created "2016-06-24" @default.
• W2049514044 creator A5011775443 @default.
• W2049514044 creator A5018970044 @default.
• W2049514044 creator A5020278626 @default.
• W2049514044 date "1998-03-01" @default.
• W2049514044 modified "2023-10-02" @default.
• W2049514044 title "The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia—in vivo study" @default.
• W2049514044 cites W1775749144 @default.
• W2049514044 cites W1971905460 @default.
• W2049514044 cites W1972899771 @default.
• W2049514044 cites W1976365732 @default.
• W2049514044 cites W1976694628 @default.
• W2049514044 cites W1982473707 @default.
• W2049514044 cites W2004123214 @default.
• W2049514044 cites W2006293323 @default.
• W2049514044 cites W2007289433 @default.
• W2049514044 cites W2010119083 @default.
• W2049514044 cites W2010547173 @default.
• W2049514044 cites W2023731942 @default.
• W2049514044 cites W2027339399 @default.
• W2049514044 cites W2035047534 @default.
• W2049514044 cites W2036758780 @default.
• W2049514044 cites W2042991737 @default.
• W2049514044 cites W2049161935 @default.
• W2049514044 cites W2049785746 @default.
• W2049514044 cites W2053124932 @default.
• W2049514044 cites W2058835315 @default.
• W2049514044 cites W2078522953 @default.
• W2049514044 cites W2078848358 @default.
• W2049514044 cites W2099108900 @default.
• W2049514044 cites W2138285095 @default.
• W2049514044 cites W2138736098 @default.
• W2049514044 cites W2156137650 @default.
• W2049514044 cites W2475553869 @default.
• W2049514044 doi "https://doi.org/10.1016/s0006-8993(97)01481-9" @default.
• W2049514044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9518618" @default.
• W2049514044 hasPublicationYear "1998" @default.
• W2049514044 type Work @default.
• W2049514044 sameAs 2049514044 @default.
• W2049514044 citedByCount "38" @default.
• W2049514044 countsByYear W20495140442012 @default.
• W2049514044 countsByYear W20495140442013 @default.
• W2049514044 countsByYear W20495140442014 @default.
• W2049514044 countsByYear W20495140442015 @default.
• W2049514044 countsByYear W20495140442016 @default.
• W2049514044 countsByYear W20495140442017 @default.
• W2049514044 countsByYear W20495140442019 @default.
• W2049514044 crossrefType "journal-article" @default.
• W2049514044 hasAuthorship W2049514044A5011775443 @default.
• W2049514044 hasAuthorship W2049514044A5018970044 @default.
• W2049514044 hasAuthorship W2049514044A5020278626 @default.
• W2049514044 hasConcept C126322002 @default.
• W2049514044 hasConcept C134018914 @default.
• W2049514044 hasConcept C150903083 @default.
• W2049514044 hasConcept C170493617 @default.
• W2049514044 hasConcept C181199279 @default.
• W2049514044 hasConcept C182683403 @default.
• W2049514044 hasConcept C185592680 @default.
• W2049514044 hasConcept C207001950 @default.
• W2049514044 hasConcept C2776991684 @default.
• W2049514044 hasConcept C2777610669 @default.
• W2049514044 hasConcept C2778815084 @default.
• W2049514044 hasConcept C2778938600 @default.
• W2049514044 hasConcept C2779652256 @default.
• W2049514044 hasConcept C2781116151 @default.
• W2049514044 hasConcept C2781161787 @default.
• W2049514044 hasConcept C34628245 @default.
• W2049514044 hasConcept C541997718 @default.
• W2049514044 hasConcept C55493867 @default.
• W2049514044 hasConcept C67907053 @default.
• W2049514044 hasConcept C71924100 @default.
• W2049514044 hasConcept C86803240 @default.
• W2049514044 hasConceptScore W2049514044C126322002 @default.
• W2049514044 hasConceptScore W2049514044C134018914 @default.
• W2049514044 hasConceptScore W2049514044C150903083 @default.
• W2049514044 hasConceptScore W2049514044C170493617 @default.
• W2049514044 hasConceptScore W2049514044C181199279 @default.
• W2049514044 hasConceptScore W2049514044C182683403 @default.
• W2049514044 hasConceptScore W2049514044C185592680 @default.
• W2049514044 hasConceptScore W2049514044C207001950 @default.
• W2049514044 hasConceptScore W2049514044C2776991684 @default.
• W2049514044 hasConceptScore W2049514044C2777610669 @default.
• W2049514044 hasConceptScore W2049514044C2778815084 @default.
• W2049514044 hasConceptScore W2049514044C2778938600 @default.
• W2049514044 hasConceptScore W2049514044C2779652256 @default.
• W2049514044 hasConceptScore W2049514044C2781116151 @default.
• W2049514044 hasConceptScore W2049514044C2781161787 @default.
• W2049514044 hasConceptScore W2049514044C34628245 @default.
• W2049514044 hasConceptScore W2049514044C541997718 @default.
• W2049514044 hasConceptScore W2049514044C55493867 @default.
• W2049514044 hasConceptScore W2049514044C67907053 @default.
• W2049514044 hasConceptScore W2049514044C71924100 @default.
• W2049514044 hasConceptScore W2049514044C86803240 @default.
• W2049514044 hasIssue "2" @default.
• W2049514044 hasLocation W20495140441 @default.
• W2049514044 hasLocation W20495140442 @default.
• W2049514044 hasOpenAccess W2049514044 @default.

• next