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- W2049529383 abstract "Previous studies demonstrate that RNA synthesis by nucleoli isolated from rat liver cells or by solubilized nucleolar polymerase is not inhibited by α-amanitin, whereas this toxin is an effective inhibitor of the extranucleolar polymerase. In contrast, administration of amanitin to intact rats severely reduces synthesis of RNA by liver nucleoli, as shown by the following results obtained 1 hr after injection of the toxin: (a) all species of RNA, including nucleolar RNA, show reduced isotope uptake from an in vivo pulse dose of orotic acid; (b) in vivo methylation of ribosomal RNA is inhibited; (c) the 45S peak of ribosomal RNA precursor disappears from gradients of nuclear RNA; and (d) RNA synthesis in vitro by nucleoli isolated from amanitin-treated rats is inhibited. The contrast between the lack of action of amanitin on RNA synthesis by isolated nucleoli and the effectiveness of the toxin in vivo suggests that ribosomal RNA formation in the intact cell is under an extranucleolar control mechanism sensitive to amanitin." @default.
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- W2049529383 date "1970-07-01" @default.
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- W2049529383 title "Evidence for extranucleolar control of RNA synthesis in the nucleolus" @default.
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- W2049529383 doi "https://doi.org/10.1016/0006-291x(70)91014-4" @default.
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