FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049529908> ?p ?o ?g. }

• W2049529908 endingPage "331" @default.
• W2049529908 startingPage "327" @default.
• W2049529908 abstract "Blood macrophages and brain macrophages (microglia) have been implicated in demyelination and destruction of the oligodendrocyte in multiple sclerosis (MS), a disease affecting primarily white matter of the central nervous system (CNS). In this study, we demonstrate that at high effector to target cell ratios, normal rat microglia exhibit a natural cytotoxicity against normal rat oligodendrocytes in vitro. The killing is not mediated by the release of soluble factors. The cytotoxic activity is upregulated by pretreatment of microglia with interferon gamma (IFNγ) or phorbol myristate acetate (PMA). Both the natural and induced cytotoxicities are inhibitable by transforming growth factor beta (TGFβ). The increase in numbers and apposition of primed or activated microglia to oligodendrocytes in MS lesions may give rise to natural or induced killing from which oligodendrocytes may be protected by TGFβ." @default.
• W2049529908 created "2016-06-24" @default.
• W2049529908 creator A5050716216 @default.
• W2049529908 creator A5065764297 @default.
• W2049529908 date "1991-01-01" @default.
• W2049529908 modified "2023-10-16" @default.
• W2049529908 title "Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF?" @default.
• W2049529908 cites W1503094954 @default.
• W2049529908 cites W1510381828 @default.
• W2049529908 cites W1515260750 @default.
• W2049529908 cites W1533311394 @default.
• W2049529908 cites W1544712871 @default.
• W2049529908 cites W1565885233 @default.
• W2049529908 cites W1579712238 @default.
• W2049529908 cites W1590384635 @default.
• W2049529908 cites W1626720272 @default.
• W2049529908 cites W1646206347 @default.
• W2049529908 cites W1730096292 @default.
• W2049529908 cites W1845938629 @default.
• W2049529908 cites W1918753726 @default.
• W2049529908 cites W1947281322 @default.
• W2049529908 cites W1960667696 @default.
• W2049529908 cites W1984858842 @default.
• W2049529908 cites W2016951403 @default.
• W2049529908 cites W2018972324 @default.
• W2049529908 cites W2023943352 @default.
• W2049529908 cites W2025392129 @default.
• W2049529908 cites W2064329226 @default.
• W2049529908 cites W2076407459 @default.
• W2049529908 cites W2077106806 @default.
• W2049529908 cites W2097417855 @default.
• W2049529908 cites W2107946445 @default.
• W2049529908 cites W2121115802 @default.
• W2049529908 cites W2135271960 @default.
• W2049529908 cites W2142177598 @default.
• W2049529908 cites W2146786154 @default.
• W2049529908 cites W2159746265 @default.
• W2049529908 doi "https://doi.org/10.1002/glia.440040311" @default.
• W2049529908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1832660" @default.
• W2049529908 hasPublicationYear "1991" @default.
• W2049529908 type Work @default.
• W2049529908 sameAs 2049529908 @default.
• W2049529908 citedByCount "124" @default.
• W2049529908 countsByYear W20495299082012 @default.
• W2049529908 countsByYear W20495299082013 @default.
• W2049529908 countsByYear W20495299082014 @default.
• W2049529908 countsByYear W20495299082015 @default.
• W2049529908 countsByYear W20495299082016 @default.
• W2049529908 countsByYear W20495299082017 @default.
• W2049529908 countsByYear W20495299082018 @default.
• W2049529908 countsByYear W20495299082019 @default.
• W2049529908 countsByYear W20495299082022 @default.
• W2049529908 crossrefType "journal-article" @default.
• W2049529908 hasAuthorship W2049529908A5050716216 @default.
• W2049529908 hasAuthorship W2049529908A5065764297 @default.
• W2049529908 hasConcept C109316439 @default.
• W2049529908 hasConcept C118131993 @default.
• W2049529908 hasConcept C154317977 @default.
• W2049529908 hasConcept C169760540 @default.
• W2049529908 hasConcept C202751555 @default.
• W2049529908 hasConcept C203014093 @default.
• W2049529908 hasConcept C2776914184 @default.
• W2049529908 hasConcept C2776985911 @default.
• W2049529908 hasConcept C2778609137 @default.
• W2049529908 hasConcept C2779830541 @default.
• W2049529908 hasConcept C2780640218 @default.
• W2049529908 hasConcept C2780884517 @default.
• W2049529908 hasConcept C529278444 @default.
• W2049529908 hasConcept C55493867 @default.
• W2049529908 hasConcept C86803240 @default.
• W2049529908 hasConcept C95444343 @default.
• W2049529908 hasConceptScore W2049529908C109316439 @default.
• W2049529908 hasConceptScore W2049529908C118131993 @default.
• W2049529908 hasConceptScore W2049529908C154317977 @default.
• W2049529908 hasConceptScore W2049529908C169760540 @default.
• W2049529908 hasConceptScore W2049529908C202751555 @default.
• W2049529908 hasConceptScore W2049529908C203014093 @default.
• W2049529908 hasConceptScore W2049529908C2776914184 @default.
• W2049529908 hasConceptScore W2049529908C2776985911 @default.
• W2049529908 hasConceptScore W2049529908C2778609137 @default.
• W2049529908 hasConceptScore W2049529908C2779830541 @default.
• W2049529908 hasConceptScore W2049529908C2780640218 @default.
• W2049529908 hasConceptScore W2049529908C2780884517 @default.
• W2049529908 hasConceptScore W2049529908C529278444 @default.
• W2049529908 hasConceptScore W2049529908C55493867 @default.
• W2049529908 hasConceptScore W2049529908C86803240 @default.
• W2049529908 hasConceptScore W2049529908C95444343 @default.
• W2049529908 hasIssue "3" @default.
• W2049529908 hasLocation W20495299081 @default.
• W2049529908 hasLocation W20495299082 @default.
• W2049529908 hasOpenAccess W2049529908 @default.
• W2049529908 hasPrimaryLocation W20495299081 @default.
• W2049529908 hasRelatedWork W1963672952 @default.
• W2049529908 hasRelatedWork W1982957701 @default.
• W2049529908 hasRelatedWork W2075896702 @default.
• W2049529908 hasRelatedWork W2086148521 @default.
• W2049529908 hasRelatedWork W2159239540 @default.
• W2049529908 hasRelatedWork W2413746452 @default.

• next