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• W2049536473 startingPage "e845" @default.
• W2049536473 abstract "Mutations and epigenetic aberrant signaling of growth factors pathways contribute to carcinogenesis. Recent studies reveal that non-coding RNAs are controllers of gene expression. H19 is an imprinted gene that demonstrates maternal monoallelic expression without a protein product; although its expression is shut off in most tissues postnatally, it is re-activated during adult tissue regeneration and tumorigenesis. Moreover, H19 is highly expressed in liver metastasis derived from a range of carcinomas. The objective of this study is to explore the role of H19 in carcinogenesis, and to determine its identification as an anti-tumor target.By controlling oxygen pressure during tumor cell growth and H19 expression levels, we investigated the role of H19 expression in vitro and in vivo in hepatocellular (HCC) and bladder carcinoma. Hypoxia upregulates the level of H19 RNA. Ablations of tumorigenicity of HCC and bladder carcinomas in vivo are seen by H19 knockdown which also significantly abrogates anchorage-independent growth after hypoxia recovery, while ectopic H19 expression enhances tumorigenic potential of carcinoma cells in vivo. Knocking-down H19 message in hypoxic stress severely diminishes p57(kip2) induction. We identified a number of potential downstream targets of H19 RNA, including angiogenin and FGF18.H19 RNA harbors pro-tumorigenic properties, thus the H19 gene behaves as an oncogene and may serve as a potential new target for anti-tumor therapy." @default.
• W2049536473 created "2016-06-24" @default.
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• W2049536473 date "2007-09-05" @default.
• W2049536473 modified "2023-09-25" @default.
• W2049536473 title "The H19 Non-Coding RNA Is Essential for Human Tumor Growth" @default.
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• W2049536473 cites W1791183955 @default.
• W2049536473 cites W1895316959 @default.
• W2049536473 cites W1905983559 @default.
• W2049536473 cites W1958115519 @default.
• W2049536473 cites W1966550470 @default.
• W2049536473 cites W1967628309 @default.
• W2049536473 cites W1969115817 @default.
• W2049536473 cites W1974350437 @default.
• W2049536473 cites W1975064579 @default.
• W2049536473 cites W1975280295 @default.
• W2049536473 cites W1981167987 @default.
• W2049536473 cites W1983811413 @default.
• W2049536473 cites W1985995844 @default.
• W2049536473 cites W1986694679 @default.
• W2049536473 cites W1987443182 @default.
• W2049536473 cites W1987856745 @default.
• W2049536473 cites W2002995168 @default.
• W2049536473 cites W2003832896 @default.
• W2049536473 cites W2010338556 @default.
• W2049536473 cites W2011378554 @default.
• W2049536473 cites W2018574431 @default.
• W2049536473 cites W2024487267 @default.
• W2049536473 cites W2025679384 @default.
• W2049536473 cites W2028032755 @default.
• W2049536473 cites W2036008499 @default.
• W2049536473 cites W2039156362 @default.
• W2049536473 cites W2042571415 @default.
• W2049536473 cites W2045844532 @default.
• W2049536473 cites W2046056065 @default.
• W2049536473 cites W2047582132 @default.
• W2049536473 cites W2052171386 @default.
• W2049536473 cites W2059267677 @default.
• W2049536473 cites W2059521326 @default.
• W2049536473 cites W2061881549 @default.
• W2049536473 cites W2062290101 @default.
• W2049536473 cites W2063517156 @default.
• W2049536473 cites W2067713115 @default.
• W2049536473 cites W2067870752 @default.
• W2049536473 cites W2077395523 @default.
• W2049536473 cites W2077610267 @default.
• W2049536473 cites W2083415193 @default.
• W2049536473 cites W2084122313 @default.
• W2049536473 cites W2088629624 @default.
• W2049536473 cites W2091444924 @default.
• W2049536473 cites W2096268611 @default.
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• W2049536473 cites W2101501894 @default.
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• W2049536473 cites W2136379850 @default.
• W2049536473 cites W2137257146 @default.
• W2049536473 cites W2137783120 @default.
• W2049536473 cites W2137784674 @default.
• W2049536473 cites W2146528974 @default.
• W2049536473 cites W2147554654 @default.
• W2049536473 cites W2150365579 @default.
• W2049536473 cites W2150936111 @default.
• W2049536473 cites W2157734320 @default.
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• W2049536473 cites W2162552052 @default.
• W2049536473 cites W2164124125 @default.
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• W2049536473 cites W2171797570 @default.
• W2049536473 cites W2172064884 @default.
• W2049536473 cites W2321164828 @default.
• W2049536473 cites W2597632520 @default.
• W2049536473 cites W2910065277 @default.
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• W2049536473 doi "https://doi.org/10.1371/journal.pone.0000845" @default.
• W2049536473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1959184" @default.
• W2049536473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17786216" @default.
• W2049536473 hasPublicationYear "2007" @default.
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