FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049552712> ?p ?o ?g. }

• W2049552712 endingPage "343" @default.
• W2049552712 startingPage "334" @default.
• W2049552712 abstract "Migration and proliferation of endothelial cells in response to VEGF play an important role in angiogenesis associated to pathologies such as atherosclerosis, diabetes and tumor development. Elevation of cAMP in endothelial cells has been shown to inhibit growth factor-induced proliferation. Our hypothesis was that inactivation of cAMP-specific phosphodiesterases (PDEs) would inhibit angiogenesis. The purpose of this study was to evaluate the effect of PDE inhibitors on in vitro and in vivo angiogenesis, using human umbilical vein endothelial cell (HUVEC) and chick chorioallantoic membrane (CAM) models respectively. Here, we report that: 1) PDE2, PDE3, PDE4 and PDE5 are expressed in HUVEC; 2) EHNA (20 microM), PDE2 selective inhibitor, and RP73401 (10 microM), PDE4 selective inhibitor, are able to increase the intracellular cAMP level in HUVEC; 3) EHNA and RP73401 are able to inhibit proliferation, cell cycle progression and migration of HUVEC stimulated by VEGF; 4) these in vitro effects can be mimic by treating HUVEC with the cAMP analogue, 8-Br-cAMP (600 microM); 5) only the association of EHNA and RP73401 inhibits in vivo angiogenesis, indicating that both migration and proliferation must be inhibited. These data strongly suggest that PDE2 and PDE4 represent new potential therapeutic targets in pathological angiogenesis." @default.
• W2049552712 created "2016-06-24" @default.
• W2049552712 creator A5039656288 @default.
• W2049552712 creator A5074157475 @default.
• W2049552712 creator A5074409733 @default.
• W2049552712 creator A5082015327 @default.
• W2049552712 creator A5086042397 @default.
• W2049552712 date "2003-01-01" @default.
• W2049552712 modified "2023-09-25" @default.
• W2049552712 title "VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors" @default.
• W2049552712 cites W103993771 @default.
• W2049552712 cites W1575134115 @default.
• W2049552712 cites W1590375747 @default.
• W2049552712 cites W1602819342 @default.
• W2049552712 cites W1775749144 @default.
• W2049552712 cites W1973519389 @default.
• W2049552712 cites W1983754425 @default.
• W2049552712 cites W1985529507 @default.
• W2049552712 cites W1987913673 @default.
• W2049552712 cites W1992896836 @default.
• W2049552712 cites W1993876642 @default.
• W2049552712 cites W1998154155 @default.
• W2049552712 cites W1998667947 @default.
• W2049552712 cites W1998709931 @default.
• W2049552712 cites W1998836600 @default.
• W2049552712 cites W1999088045 @default.
• W2049552712 cites W1999855214 @default.
• W2049552712 cites W2000000541 @default.
• W2049552712 cites W2000217470 @default.
• W2049552712 cites W2001536471 @default.
• W2049552712 cites W2006293229 @default.
• W2049552712 cites W2029226821 @default.
• W2049552712 cites W2036246796 @default.
• W2049552712 cites W2037275196 @default.
• W2049552712 cites W2039812666 @default.
• W2049552712 cites W2042397185 @default.
• W2049552712 cites W2042662803 @default.
• W2049552712 cites W2044603696 @default.
• W2049552712 cites W2052611104 @default.
• W2049552712 cites W2054056891 @default.
• W2049552712 cites W2059822315 @default.
• W2049552712 cites W2070038803 @default.
• W2049552712 cites W2075603196 @default.
• W2049552712 cites W2077254675 @default.
• W2049552712 cites W2081192590 @default.
• W2049552712 cites W2081429182 @default.
• W2049552712 cites W2088763860 @default.
• W2049552712 cites W2095126097 @default.
• W2049552712 cites W2095774675 @default.
• W2049552712 cites W2096791952 @default.
• W2049552712 cites W2124977672 @default.
• W2049552712 cites W2146787008 @default.
• W2049552712 cites W2150258341 @default.
• W2049552712 cites W2158438681 @default.
• W2049552712 cites W2166389885 @default.
• W2049552712 cites W2274550965 @default.
• W2049552712 cites W2406815902 @default.
• W2049552712 cites W4231258015 @default.
• W2049552712 doi "https://doi.org/10.1160/th03-02-0084" @default.
• W2049552712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12888882" @default.
• W2049552712 hasPublicationYear "2003" @default.
• W2049552712 type Work @default.
• W2049552712 sameAs 2049552712 @default.
• W2049552712 citedByCount "90" @default.
• W2049552712 countsByYear W20495527122012 @default.
• W2049552712 countsByYear W20495527122013 @default.
• W2049552712 countsByYear W20495527122014 @default.
• W2049552712 countsByYear W20495527122015 @default.
• W2049552712 countsByYear W20495527122016 @default.
• W2049552712 countsByYear W20495527122017 @default.
• W2049552712 countsByYear W20495527122018 @default.
• W2049552712 countsByYear W20495527122019 @default.
• W2049552712 countsByYear W20495527122020 @default.
• W2049552712 countsByYear W20495527122021 @default.
• W2049552712 countsByYear W20495527122022 @default.
• W2049552712 countsByYear W20495527122023 @default.
• W2049552712 crossrefType "journal-article" @default.
• W2049552712 hasAuthorship W2049552712A5039656288 @default.
• W2049552712 hasAuthorship W2049552712A5074157475 @default.
• W2049552712 hasAuthorship W2049552712A5074409733 @default.
• W2049552712 hasAuthorship W2049552712A5082015327 @default.
• W2049552712 hasAuthorship W2049552712A5086042397 @default.
• W2049552712 hasConcept C123012128 @default.
• W2049552712 hasConcept C126322002 @default.
• W2049552712 hasConcept C134018914 @default.
• W2049552712 hasConcept C137738243 @default.
• W2049552712 hasConcept C146285616 @default.
• W2049552712 hasConcept C167734588 @default.
• W2049552712 hasConcept C202751555 @default.
• W2049552712 hasConcept C2776770532 @default.
• W2049552712 hasConcept C2776991684 @default.
• W2049552712 hasConcept C2777025900 @default.
• W2049552712 hasConcept C2777411675 @default.
• W2049552712 hasConcept C2777834122 @default.
• W2049552712 hasConcept C2780394083 @default.
• W2049552712 hasConcept C34628245 @default.
• W2049552712 hasConcept C502942594 @default.
• W2049552712 hasConcept C55493867 @default.

• next