FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049553003> ?p ?o ?g. }

• W2049553003 endingPage "650" @default.
• W2049553003 startingPage "641" @default.
• W2049553003 abstract "Summary The fusion protein TEL/PDGFRB is associated with chronic myelomonocytic leukaemia and has intrinsic tyrosine kinase activity. The effects of TEL/PDGFRB were assessed using the multipotent haemopoietic cell line FDCP‐Mix. In the absence of growth factors, TEL/PDGFRB expression increased survival that was associated with elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PIP3). Whilst TEL/PDGFRB had subtle effects on the growth factor requirements it had a profound effect on differentiation. The cells became refractory to cytokine‐stimulated development, showing limited maturation but failing to produce fully mature cells. We have previously identified the spliceosome protein THOC5 as a target in macrophage colony‐stimulating factor signalling and a protein involved in the regulation of transcription factor expression. TEL/PDGFRB expression increased the expression and phosphorylation of THOC5. Elevated expression of THOC5 increased PIP3 levels and decreased apoptosis. Mass spectrometry was used to identify a site for TEL/PDGFRB‐mediated phosphorylation on THOC5, which was shown to be a target for a number of other leukaemogenic tyrosine kinases. Thus, THOC5 is a novel target for modulation of signal transduction with a potential role in leukaemogenesis." @default.
• W2049553003 created "2016-06-24" @default.
• W2049553003 creator A5011429002 @default.
• W2049553003 creator A5019334319 @default.
• W2049553003 creator A5023353147 @default.
• W2049553003 creator A5029748845 @default.
• W2049553003 creator A5037497459 @default.
• W2049553003 creator A5043371399 @default.
• W2049553003 creator A5068545702 @default.
• W2049553003 creator A5081478540 @default.
• W2049553003 creator A5085508344 @default.
• W2049553003 creator A5090203483 @default.
• W2049553003 date "2008-04-15" @default.
• W2049553003 modified "2023-10-16" @default.
• W2049553003 title "THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover" @default.
• W2049553003 cites W129835611 @default.
• W2049553003 cites W1999160210 @default.
• W2049553003 cites W2004714475 @default.
• W2049553003 cites W2015096009 @default.
• W2049553003 cites W2018794044 @default.
• W2049553003 cites W2023544072 @default.
• W2049553003 cites W2029076588 @default.
• W2049553003 cites W2036180570 @default.
• W2049553003 cites W2051112982 @default.
• W2049553003 cites W2055379575 @default.
• W2049553003 cites W2059664449 @default.
• W2049553003 cites W2059902938 @default.
• W2049553003 cites W2065285374 @default.
• W2049553003 cites W2069934198 @default.
• W2049553003 cites W2077173862 @default.
• W2049553003 cites W2078336183 @default.
• W2049553003 cites W2105192683 @default.
• W2049553003 cites W2110007614 @default.
• W2049553003 cites W2117291755 @default.
• W2049553003 cites W2117563665 @default.
• W2049553003 cites W2121464784 @default.
• W2049553003 cites W2140583946 @default.
• W2049553003 cites W2150224626 @default.
• W2049553003 cites W2163153806 @default.
• W2049553003 cites W2169179093 @default.
• W2049553003 cites W271615412 @default.
• W2049553003 cites W4241058123 @default.
• W2049553003 cites W4248663651 @default.
• W2049553003 cites W43324733 @default.
• W2049553003 doi "https://doi.org/10.1111/j.1365-2141.2008.07090.x" @default.
• W2049553003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18373705" @default.
• W2049553003 hasPublicationYear "2008" @default.
• W2049553003 type Work @default.
• W2049553003 sameAs 2049553003 @default.
• W2049553003 citedByCount "19" @default.
• W2049553003 countsByYear W20495530032012 @default.
• W2049553003 countsByYear W20495530032013 @default.
• W2049553003 countsByYear W20495530032014 @default.
• W2049553003 countsByYear W20495530032015 @default.
• W2049553003 countsByYear W20495530032016 @default.
• W2049553003 countsByYear W20495530032021 @default.
• W2049553003 countsByYear W20495530032022 @default.
• W2049553003 countsByYear W20495530032023 @default.
• W2049553003 crossrefType "journal-article" @default.
• W2049553003 hasAuthorship W2049553003A5011429002 @default.
• W2049553003 hasAuthorship W2049553003A5019334319 @default.
• W2049553003 hasAuthorship W2049553003A5023353147 @default.
• W2049553003 hasAuthorship W2049553003A5029748845 @default.
• W2049553003 hasAuthorship W2049553003A5037497459 @default.
• W2049553003 hasAuthorship W2049553003A5043371399 @default.
• W2049553003 hasAuthorship W2049553003A5068545702 @default.
• W2049553003 hasAuthorship W2049553003A5081478540 @default.
• W2049553003 hasAuthorship W2049553003A5085508344 @default.
• W2049553003 hasAuthorship W2049553003A5090203483 @default.
• W2049553003 hasConcept C104317684 @default.
• W2049553003 hasConcept C153911025 @default.
• W2049553003 hasConcept C170493617 @default.
• W2049553003 hasConcept C185592680 @default.
• W2049553003 hasConcept C2775960820 @default.
• W2049553003 hasConcept C2777553839 @default.
• W2049553003 hasConcept C42362537 @default.
• W2049553003 hasConcept C502942594 @default.
• W2049553003 hasConcept C55493867 @default.
• W2049553003 hasConcept C62478195 @default.
• W2049553003 hasConcept C78221974 @default.
• W2049553003 hasConcept C86803240 @default.
• W2049553003 hasConcept C95444343 @default.
• W2049553003 hasConceptScore W2049553003C104317684 @default.
• W2049553003 hasConceptScore W2049553003C153911025 @default.
• W2049553003 hasConceptScore W2049553003C170493617 @default.
• W2049553003 hasConceptScore W2049553003C185592680 @default.
• W2049553003 hasConceptScore W2049553003C2775960820 @default.
• W2049553003 hasConceptScore W2049553003C2777553839 @default.
• W2049553003 hasConceptScore W2049553003C42362537 @default.
• W2049553003 hasConceptScore W2049553003C502942594 @default.
• W2049553003 hasConceptScore W2049553003C55493867 @default.
• W2049553003 hasConceptScore W2049553003C62478195 @default.
• W2049553003 hasConceptScore W2049553003C78221974 @default.
• W2049553003 hasConceptScore W2049553003C86803240 @default.
• W2049553003 hasConceptScore W2049553003C95444343 @default.
• W2049553003 hasIssue "5" @default.
• W2049553003 hasLocation W20495530031 @default.
• W2049553003 hasLocation W20495530032 @default.

• next