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• W2049553627 abstract "A spiral inertial filtration (SIFT) device that is capable of high-throughput (1 ml/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude is reported. This device is able to remove large fractions of sample fluid from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and Dean drag forces. To enable the calculation of channel geometries in the SIFT microsystem for specific concentration factors, an equivalent circuit model was developed and experimentally validated. Large particle concentration factors were then achieved by maintaining either the average fluid velocity or the Dean number throughout the entire length of the channel during the incremental removal of sample fluid. The SIFT device was able to separate MCF7 cells spiked into whole blood from the non-target white blood cells (WBC) with a recovery of nearly 100% while removing 93% of the sample volume, which resulted in a concentration enhancement of the MCF7 cancer cells by a factor of 14." @default.
• W2049553627 created "2016-06-24" @default.
• W2049553627 creator A5076728371 @default.
• W2049553627 creator A5077974221 @default.
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• W2049553627 creator A5090429250 @default.
• W2049553627 date "2014-03-01" @default.
• W2049553627 modified "2023-10-16" @default.
• W2049553627 title "High-throughput particle separation and concentration using spiral inertial filtration" @default.
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• W2049553627 doi "https://doi.org/10.1063/1.4870399" @default.
• W2049553627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3976465" @default.
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• W2049553627 hasPublicationYear "2014" @default.
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