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- W2049562010 abstract "[7, 9, 13], which were derived from the strains with the taster allele Sac, exhibited much less preference for sugar and alcohol solutions in long-term preference tests. However, these testing techniques, although most commonly used, do not permit differentiating the role of taste from the postabsorptive effects (intoxicating and metabolic) in the reaction of alcohol preference. Further study is also required to confirm the perception of the ethanol sweet component by mice, as well as the fact that T1R3 protein is responsible for the perception. In this study, we used the brief-access taste test minimizing the time of contact with the test substance and reducing the volume of its consumption. As a result, the contribution of postabsorptive effects is reduced. Here, we analyzed the response of C57BL/6ByJ, 129P3/J, and Tas1r3-knockout mice to alcohol and two prototypical taste components, sweet and bitter. The presence of the non-taster allele of the Sac d locus in 129P3/J mice or complete absence of the Sac locus (Tas1r3−/− mice) was found to predetermine rejection of ethanol. Note that Sac affected neither perception of the bitter component nor the gustatory detection of ethanol." @default.
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- W2049562010 date "2010-06-01" @default.
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- W2049562010 title "The role of the Sac locus in the alcohol taste preference in inbred mouse strains" @default.
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- W2049562010 doi "https://doi.org/10.1134/s001249661003004x" @default.
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