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• W2049562836 abstract "Ectopic coexpression of the two chains of the Type I and Type III interferon (IFN) receptor complexes (IFN-αR1 and IFN-αR2c, or IFN-λR1 and IL-10R2) yielded sensitivity to IFN-alpha or IFN-lambda in only some cells. We found that IFN-αR1 and IFN-αR2c exhibit FRET only when expressed at equivalent and low levels. Expanded clonal cell lines expressing both IFN-αR1 and IFN-αR2c were sensitive to IFN-alpha only when IFN-αR1 and IFN-αR2c exhibited FRET in the absence of human IFN-alpha. Coexpression of RACK-1 or Jak1 enhanced the affinity of the interaction between IFN-αR1 and IFN-αR2c. Both IFN-αR1 and IFN-αR2c exhibited FRET with Jak1 and Tyk2. Together with data showing that disruption of the preassociation between the IFN-gamma receptor chains inhibited its biological activity, we propose that biologically active IFN receptors require ligand-independent juxtaposition of IFN receptor chains assisted by their associated cytosolic proteins." @default.
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• W2049562836 date "2013-10-01" @default.
• W2049562836 modified "2023-09-26" @default.
• W2049562836 title "Ligand-independent interaction of the type I interferon receptor complex is necessary to observe its biological activity" @default.
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• W2049562836 doi "https://doi.org/10.1016/j.cyto.2013.06.309" @default.
• W2049562836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3770802" @default.
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