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- W2049565583 abstract "A method is described for the rapid HPLC analysis of a number of anticonvulsant drugs in vitreous humour by injection directly onto a preconcentration column without the need for prior extraction. The conditions for optimum precision and accuracy were investigated and the method was subsequently applied to the analysis of phenytoin in a number of overdose cases. Sensitivity was 0.05 microgram/ml on a 0.5 ml vitreous sample. The mean blood/vitreous ratio for phenytoin was found to be 2.8 (range: 1.4-5.1). The relationship between blood and vitreous levels had a correlation coefficient of 0.85. Vitreous was found to be a very clean, stable sample, ideally suited to this technique." @default.
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- W2049565583 date "1989-04-01" @default.
- W2049565583 modified "2023-10-14" @default.
- W2049565583 title "Direct analysis of anticonvulsant drugs in vitreous humour by HPLC using a column switching technique" @default.
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- W2049565583 doi "https://doi.org/10.1016/0379-0738(89)90244-2" @default.
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