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- W2049590936 abstract "Mutations at the disconnected ( disco) locus in Drosophila melanogaster cause cultures of this insect to eclose in an essentially arrhythmic manner and also nearly eliminate free-running circadian rhythms of locomotor activity. Yet disco mutants are not totally light- insensitive : Whereas they performed very poorly in tests of certain behavioral responses to visual stimuli, they were able to exhibit forced periodic locomotor activity under conditions of light-dark cycling. We discuss these results in the context of (1) the dispensability of this insect's external photoreceptors for entrainment of its circadian pacemaker, and (2) possible disco-induced abnormalities in the connections of extraocular photoreceptors to their targets in the central nervous system and/or abnormalities in the targets themselves—which presum ably include elements of the fly's circadian clock." @default.
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- W2049590936 date "1989-03-01" @default.
- W2049590936 modified "2023-10-15" @default.
- W2049590936 title "The disconnected Visual System Mutations in Drosophila melanogaster Drastically Disrupt Circadian Rhythms" @default.
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- W2049590936 doi "https://doi.org/10.1177/074873048900400101" @default.
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