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- W2049592544 abstract "Although immunity in multicellular organisms is efficient in dealing with alien agents, it may fail for allogeneic chimerism. Natural chimerism is widely documented in nature, distributed in at least ten phyla of protists, invertebrates and plants, vertebrates and mammals, including humans; it is an important ecological/evolutionary tool manipulating metazoans' life history portraits. Instead of purging allogeneic nascent selfish cells, a 'double edged sword' chimerism emerges, displaying environmental dictated costs and benefits for the genotypes involved. Benefits include the development of synergistic complementation, the increase of genetic variability, the assurance of mate location, improved size-dependent ecological qualities (growth rates, reproduction, survivorship, competition, environmental tolerance) and more. Costs include the threat of somatic and germ cell parasitism, developmental instability, death, diseases, autoimmunity, sexual sterility and organ malformations, which develop as well in mammalian natural chimerism, including humans. Because of its importance, medical sciences should study and harness natural chimerism properties for clinical purposes." @default.
- W2049592544 created "2016-06-24" @default.
- W2049592544 creator A5090421412 @default.
- W2049592544 date "2011-01-01" @default.
- W2049592544 modified "2023-09-29" @default.
- W2049592544 title "Quo vadis chimerism?" @default.
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- W2049592544 doi "https://doi.org/10.4161/chim.2.1.14725" @default.
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