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• W2049636331 endingPage "10904" @default.
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• W2049636331 abstract "Mutations in the insulin/IGF-1 neuroendocrine pathway extend lifespan and affect development, metabolism, and other biological processes in Caenorhabditis elegans and in other species. In addition, they may play a role in learning and memory. Investigation of the insulin/IGF-1 pathway may provide clues for the prevention of age-related declines in cognitive functions. Here, we examined the effects of the life-extending (Age) mutations, such as the age-1 (phosphatidylinositol 3-OH kinase) and daf-2 (insulin/IGF-1 receptor) mutations, on associative learning behavior called isothermal tracking. This thermotaxis learning behavior associates paired stimuli, temperature, and food. The age-1 mutation delayed the age-related decline of isothermal tracking, resulting in a 210% extension of the period that ensures it. The effect is dramatic compared with the extension of other physiological health spans. In addition, young adults of various Age mutants ( age-1 , daf-2 , clk-1 , and eat-2 ) showed increased consistency of temperature-food association, which may be caused by a common feature of the mutants, such as the secondary effects of life extension (i.e., enhanced maintenance of neural mechanisms). The age-1 and daf-2 mutants but not the other Age mutants showed an increase in temperature-starvation association through a different mechanism. Increased temperature-food association of the daf-2 mutant was dependent on neuronal Ca 2+ -sensor ncs-1 , which modulates isothermal tracking in the AIY interneuron. Interestingly, mutations in the daf-7 TGFβ gene, which functions in parallel to the insulin/IGF-1 pathway, caused deficits in acquisition of temperature-food and temperature-starvation association. This study highlights roles of the Age mutations in modulation of certain behavioral plasticity." @default.
• W2049636331 created "2016-06-24" @default.
• W2049636331 creator A5070135323 @default.
• W2049636331 creator A5072415149 @default.
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• W2049636331 creator A5086415350 @default.
• W2049636331 date "2005-11-23" @default.
• W2049636331 modified "2023-10-01" @default.
• W2049636331 title "Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal in<i>Caenorhabditis elegans</i>" @default.
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• W2049636331 doi "https://doi.org/10.1523/jneurosci.3600-04.2005" @default.
• W2049636331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725869" @default.
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