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- W2049641301 abstract "KSHV is the etiologic agent for Kaposi’s sarcoma (KS), a neoplasm that manifests most aggressively as multifocal lesions on parts of human skin with a propensity for inflammatory reactivity. However, mechanisms that control evolution of KS from a benign hyperplasia to the histologically complex cutaneous lesion remain unknown. In this study, we found that KSHV induces proteomic and morphological changes in melanocytes and melanoma-derived cell lines, accompanied by deregulation of the endogenous anti-inflammatory responses anchored by the MC1-R/ α -MSH signaling axis. We also identified two skin-derived cell lines that displayed differences in ability to support long-term KSHV infection and mapped this dichotomy to differences in (a) NF- κ B activation status, (b) processing and expression of KSHV latency-associated nuclear antigen isoforms putatively associated with the viral lytic cycle, and (c) susceptibility to virus-induced changes in expression of key anti-inflammatory response genes that antagonize NF- κ B, including MC1-R, POMC, TRP-1, and xCT. Viral subversion of molecules that control the balance between latency and lytic replication represents a novel correlate of KSHV pathogenesis and tropism in skin and underscores the potential benefit of harnessing the endogenous anti-inflammatory processes as a therapeutic option for attenuating cutaneous KS and other proinflammatory outcomes of KSHV infection in high-risk individuals." @default.
- W2049641301 created "2016-06-24" @default.
- W2049641301 creator A5007316009 @default.
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- W2049641301 creator A5039872869 @default.
- W2049641301 creator A5049953188 @default.
- W2049641301 creator A5053258826 @default.
- W2049641301 date "2014-01-01" @default.
- W2049641301 modified "2023-09-27" @default.
- W2049641301 title "Kaposi’s Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis" @default.
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- W2049641301 doi "https://doi.org/10.1155/2014/246076" @default.
- W2049641301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3951102" @default.
- W2049641301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24701351" @default.
- W2049641301 hasPublicationYear "2014" @default.
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