Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049658049> ?p ?o ?g. }
- W2049658049 endingPage "63" @default.
- W2049658049 startingPage "56" @default.
- W2049658049 abstract "Arsenic and cadmium (Cd(+2)) are human carcinogens, and epidemiological studies have implicated both pollutants in the development of urinary bladder cancer. Despite this epidemiological base, it is unknown if either Cd(+2) or arsenite (As(+3)) can directly cause the malignant transformation of human urothelial cells. The goal of this study was to determine if Cd(+2) and/or As(+3) are able to cause the malignant transformation of human urothelial cells. The strategy employed was to expose the nontumorigenic urothelial cell line UROtsa to long-term in vitro exposure to Cd(+2) and As(+3), with the endpoint being the ability of the cells to form colonies in soft agar and tumors when heterotransplanted into nude mice. It was demonstrated that a long-term exposure to either 1 M Cd(+2) or 1 M As(+3) resulted in the selection of cells that were able to form colonies in soft agar and tumors when heterotransplanted into nude mice. The histology of the tumor heterotransplants produced by UROtsa cells malignantly transformed by Cd(+2) had epithelial features consistent with those of a classic transitional-cell carcinoma of the bladder. The histology of the tumor heterotransplants produced by cells malignantly transformed by As(+3) was unique in that the cells displayed a prominent squamoid differentiation." @default.
- W2049658049 created "2016-06-24" @default.
- W2049658049 creator A5009658338 @default.
- W2049658049 creator A5033798889 @default.
- W2049658049 creator A5041586597 @default.
- W2049658049 creator A5067513073 @default.
- W2049658049 creator A5068566357 @default.
- W2049658049 creator A5081166985 @default.
- W2049658049 date "2004-01-21" @default.
- W2049658049 modified "2023-10-01" @default.
- W2049658049 title "Inorganic Cadmium- and Arsenite-Induced Malignant Transformation of Human Bladder Urothelial Cells" @default.
- W2049658049 cites W1563001390 @default.
- W2049658049 cites W1629179716 @default.
- W2049658049 cites W1633473664 @default.
- W2049658049 cites W1972504105 @default.
- W2049658049 cites W198362610 @default.
- W2049658049 cites W1991166887 @default.
- W2049658049 cites W1996173918 @default.
- W2049658049 cites W2016001433 @default.
- W2049658049 cites W2016085865 @default.
- W2049658049 cites W2017903205 @default.
- W2049658049 cites W2019486900 @default.
- W2049658049 cites W2024161928 @default.
- W2049658049 cites W2035029439 @default.
- W2049658049 cites W2038673475 @default.
- W2049658049 cites W2047439811 @default.
- W2049658049 cites W2050925663 @default.
- W2049658049 cites W2059115578 @default.
- W2049658049 cites W2101864774 @default.
- W2049658049 cites W2151681632 @default.
- W2049658049 cites W2164063181 @default.
- W2049658049 cites W2219880628 @default.
- W2049658049 doi "https://doi.org/10.1093/toxsci/kfh086" @default.
- W2049658049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14976345" @default.
- W2049658049 hasPublicationYear "2004" @default.
- W2049658049 type Work @default.
- W2049658049 sameAs 2049658049 @default.
- W2049658049 citedByCount "108" @default.
- W2049658049 countsByYear W20496580492012 @default.
- W2049658049 countsByYear W20496580492013 @default.
- W2049658049 countsByYear W20496580492014 @default.
- W2049658049 countsByYear W20496580492015 @default.
- W2049658049 countsByYear W20496580492016 @default.
- W2049658049 countsByYear W20496580492017 @default.
- W2049658049 countsByYear W20496580492018 @default.
- W2049658049 countsByYear W20496580492019 @default.
- W2049658049 countsByYear W20496580492020 @default.
- W2049658049 countsByYear W20496580492021 @default.
- W2049658049 countsByYear W20496580492023 @default.
- W2049658049 crossrefType "journal-article" @default.
- W2049658049 hasAuthorship W2049658049A5009658338 @default.
- W2049658049 hasAuthorship W2049658049A5033798889 @default.
- W2049658049 hasAuthorship W2049658049A5041586597 @default.
- W2049658049 hasAuthorship W2049658049A5067513073 @default.
- W2049658049 hasAuthorship W2049658049A5068566357 @default.
- W2049658049 hasAuthorship W2049658049A5081166985 @default.
- W2049658049 hasBestOaLocation W20496580492 @default.
- W2049658049 hasConcept C114246631 @default.
- W2049658049 hasConcept C126322002 @default.
- W2049658049 hasConcept C142724271 @default.
- W2049658049 hasConcept C178790620 @default.
- W2049658049 hasConcept C185592680 @default.
- W2049658049 hasConcept C202751555 @default.
- W2049658049 hasConcept C2776305511 @default.
- W2049658049 hasConcept C2777540882 @default.
- W2049658049 hasConcept C2779762690 @default.
- W2049658049 hasConcept C2910041100 @default.
- W2049658049 hasConcept C31033888 @default.
- W2049658049 hasConcept C502230775 @default.
- W2049658049 hasConcept C502942594 @default.
- W2049658049 hasConcept C54355233 @default.
- W2049658049 hasConcept C57742111 @default.
- W2049658049 hasConcept C71924100 @default.
- W2049658049 hasConcept C81885089 @default.
- W2049658049 hasConcept C86803240 @default.
- W2049658049 hasConceptScore W2049658049C114246631 @default.
- W2049658049 hasConceptScore W2049658049C126322002 @default.
- W2049658049 hasConceptScore W2049658049C142724271 @default.
- W2049658049 hasConceptScore W2049658049C178790620 @default.
- W2049658049 hasConceptScore W2049658049C185592680 @default.
- W2049658049 hasConceptScore W2049658049C202751555 @default.
- W2049658049 hasConceptScore W2049658049C2776305511 @default.
- W2049658049 hasConceptScore W2049658049C2777540882 @default.
- W2049658049 hasConceptScore W2049658049C2779762690 @default.
- W2049658049 hasConceptScore W2049658049C2910041100 @default.
- W2049658049 hasConceptScore W2049658049C31033888 @default.
- W2049658049 hasConceptScore W2049658049C502230775 @default.
- W2049658049 hasConceptScore W2049658049C502942594 @default.
- W2049658049 hasConceptScore W2049658049C54355233 @default.
- W2049658049 hasConceptScore W2049658049C57742111 @default.
- W2049658049 hasConceptScore W2049658049C71924100 @default.
- W2049658049 hasConceptScore W2049658049C81885089 @default.
- W2049658049 hasConceptScore W2049658049C86803240 @default.
- W2049658049 hasIssue "1" @default.
- W2049658049 hasLocation W20496580491 @default.
- W2049658049 hasLocation W20496580492 @default.
- W2049658049 hasLocation W20496580493 @default.
- W2049658049 hasOpenAccess W2049658049 @default.