FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049658246> ?p ?o ?g. }

• W2049658246 endingPage "2071" @default.
• W2049658246 startingPage "2062" @default.
• W2049658246 abstract "Mucin 1 (MUC1) is a diagnostic factor and therapy target in lung adenocarcinoma. MUC1 C-terminal intracellular domain (CD) interacts with estrogen receptor (ER) α and increases gene transcription in breast cancer cells. Because lung adenocarcinoma cells express functional ERα and ERβ, we examined MUC1 expression and MUC1-ER interaction. Because blocking MUC1 CD with an inhibitory peptide (PMIP) inhibited breast tumor growth, we tested whether PMIP would inhibit lung adenocarcinoma cell proliferation. We report that MUC1 interacts with ERα and ERβ within the nucleus of H1793 lung adenocarcinoma cells in accordance with MUC1 expression. PMIP was taken up by H23 and H1793 cells and inhibited the proliferation of H1793, but not H23 cells, concordant with higher MUC1 protein expression in H1793 cells. Lower MUC1 protein expression in H23 does not correspond to microRNAs miR-125b and miR-145 that have been reported to reduce MUC1 expression. PMIP had no effect on the viability of normal human bronchial epithelial cells, which lack MUC1 expression. PMIP inhibited estradiol-activated reporter gene transcription and endogenous cyclin D1 and nuclear respiratory factor-1 gene transcription in H1793 cells. These results indicate MUC1-ER functional interaction in lung adenocarcinoma cells and that inhibiting MUC1 inhibits lung adenocarcinoma cell viability." @default.
• W2049658246 created "2016-06-24" @default.
• W2049658246 creator A5002553804 @default.
• W2049658246 creator A5046637632 @default.
• W2049658246 creator A5070981762 @default.
• W2049658246 creator A5078066178 @default.
• W2049658246 creator A5080064738 @default.
• W2049658246 creator A5082292962 @default.
• W2049658246 creator A5091258654 @default.
• W2049658246 date "2011-11-01" @default.
• W2049658246 modified "2023-09-22" @default.
• W2049658246 title "Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells" @default.
• W2049658246 cites W1970484324 @default.
• W2049658246 cites W1974881054 @default.
• W2049658246 cites W1994708622 @default.
• W2049658246 cites W1995331478 @default.
• W2049658246 cites W2005035060 @default.
• W2049658246 cites W2005354740 @default.
• W2049658246 cites W2011770154 @default.
• W2049658246 cites W2016700676 @default.
• W2049658246 cites W2016820476 @default.
• W2049658246 cites W2018446899 @default.
• W2049658246 cites W2020451319 @default.
• W2049658246 cites W2021049263 @default.
• W2049658246 cites W2021845302 @default.
• W2049658246 cites W2025046214 @default.
• W2049658246 cites W2027104228 @default.
• W2049658246 cites W2031056915 @default.
• W2049658246 cites W2033504349 @default.
• W2049658246 cites W2052953366 @default.
• W2049658246 cites W2062672501 @default.
• W2049658246 cites W2070020986 @default.
• W2049658246 cites W2071993616 @default.
• W2049658246 cites W2081768971 @default.
• W2049658246 cites W2101314927 @default.
• W2049658246 cites W2101591039 @default.
• W2049658246 cites W2101976092 @default.
• W2049658246 cites W2103063075 @default.
• W2049658246 cites W2113574317 @default.
• W2049658246 cites W2121804957 @default.
• W2049658246 cites W2123603056 @default.
• W2049658246 cites W2128735213 @default.
• W2049658246 cites W2142686295 @default.
• W2049658246 cites W2144769750 @default.
• W2049658246 cites W2146426819 @default.
• W2049658246 cites W2153768616 @default.
• W2049658246 cites W2154705763 @default.
• W2049658246 cites W2157105746 @default.
• W2049658246 cites W2162097274 @default.
• W2049658246 cites W2165222588 @default.
• W2049658246 cites W2171050628 @default.
• W2049658246 cites W28705092 @default.
• W2049658246 cites W4328001267 @default.
• W2049658246 doi "https://doi.org/10.1158/1535-7163.mct-11-0381" @default.
• W2049658246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3213286" @default.
• W2049658246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21862684" @default.
• W2049658246 hasPublicationYear "2011" @default.
• W2049658246 type Work @default.
• W2049658246 sameAs 2049658246 @default.
• W2049658246 citedByCount "24" @default.
• W2049658246 countsByYear W20496582462012 @default.
• W2049658246 countsByYear W20496582462013 @default.
• W2049658246 countsByYear W20496582462014 @default.
• W2049658246 countsByYear W20496582462015 @default.
• W2049658246 countsByYear W20496582462017 @default.
• W2049658246 countsByYear W20496582462018 @default.
• W2049658246 countsByYear W20496582462019 @default.
• W2049658246 countsByYear W20496582462020 @default.
• W2049658246 countsByYear W20496582462021 @default.
• W2049658246 countsByYear W20496582462022 @default.
• W2049658246 crossrefType "journal-article" @default.
• W2049658246 hasAuthorship W2049658246A5002553804 @default.
• W2049658246 hasAuthorship W2049658246A5046637632 @default.
• W2049658246 hasAuthorship W2049658246A5070981762 @default.
• W2049658246 hasAuthorship W2049658246A5078066178 @default.
• W2049658246 hasAuthorship W2049658246A5080064738 @default.
• W2049658246 hasAuthorship W2049658246A5082292962 @default.
• W2049658246 hasAuthorship W2049658246A5091258654 @default.
• W2049658246 hasBestOaLocation W20496582461 @default.
• W2049658246 hasConcept C104317684 @default.
• W2049658246 hasConcept C121608353 @default.
• W2049658246 hasConcept C126322002 @default.
• W2049658246 hasConcept C150194340 @default.
• W2049658246 hasConcept C153911025 @default.
• W2049658246 hasConcept C161733203 @default.
• W2049658246 hasConcept C179264091 @default.
• W2049658246 hasConcept C2777421810 @default.
• W2049658246 hasConcept C2781182431 @default.
• W2049658246 hasConcept C502942594 @default.
• W2049658246 hasConcept C530470458 @default.
• W2049658246 hasConcept C55493867 @default.
• W2049658246 hasConcept C62112901 @default.
• W2049658246 hasConcept C71924100 @default.
• W2049658246 hasConcept C84606932 @default.
• W2049658246 hasConcept C86339819 @default.
• W2049658246 hasConcept C86803240 @default.
• W2049658246 hasConceptScore W2049658246C104317684 @default.
• W2049658246 hasConceptScore W2049658246C121608353 @default.

• next