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- W2049660192 abstract "Abstract The use of steroid drugs bound covalently to hyaluronate through ester linkages has been proposed for local treatment of arthritic diseases. The in vitro release profile of HYC 141, formed by linking covalently methylprednisolone to a soluble high molecular weight hyaluronate matrix, was studied. First, the influence of various parameters (temperature, pH, protein content, viscosity), in the range of the physiopathological values, was investigated in buffer medium. The release of methylprednisolone was five-fold slower at 20°C than at 37°C and diminished further when the HYC 141 concentration was increased. The HYC 141 was more stable below neutral pH than above it, and this was not dependent on the protein content of the medium. Secondly, the release of methylprednisolone was studied in plasma and synovial fluid from patients with inflammatory arthritides. The T50% was similar in both samples and ranged from 3.2 to 5.9 h, but was faster than in phosphate buffer of corresponding pH (22–39 h). These results suggest that the release profile of HYC 141 depends on the physico-chemical parameters of the medium and possibly on the chemical conformation of hyaluronate. In human samples, hydrolysis seems to be controlled by an esterase activity. This hypothesis was strengthened by using an acylating inhibitor that reduces the hydrolysis rate of ester linkages." @default.
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- W2049660192 date "1995-05-01" @default.
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- W2049660192 title "In vitro drug release from HYC 141, a corticosteroid ester of high molecular weight hyaluronan" @default.
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