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• W2049664564 abstract "The function of P-glycoproteins In 1976, Juliano & Ling discovered a plasma membrane protein that is overexpressed in colchicineresistant tumor cells (1). They called it P-glycoprotein (Pgp) because it was assumed to be involved in the permeation of these drugs across the plasma membrane. Subsequent cloning of its cDNA revealed that P-glycoproteins represent a small family of isozymes. In mice, three genes were found to encode for Pgp’s: mdrl, mdr2 and mdr3. Because of their high homology, mdrl and mdr3 were later renamed mdrlb and mdrla, respectively. In man, two genes were characterized, MDRl and MDR3. High homology was observed between the mouse mdr2 and the human MDR3 genes. Analysis of the genes revealed that they encoded for so-called ABC transporters, a large family of proteins which possess ATP-binding domains and are involved in active transmembrane transport (2,3). Transfection of cells with the human MDRl or the mouse mdrla or mdrlb gene indicated that these P-glycoproteins conferred multidrug resistance against amphipathic drugs by extrusion of these compounds out of the cell (4,5). Strikingly, transfection of cells with the mouse mdr2 or the highly homologous human MDR3 gene did not confer such multidrug resistance to the cells. On the basis of their homology with the other P-glycoproteins it was assumed, however, that mdd and MDR3 Pgp were ATPdependent transporters as well. The expression of the various Pgp’s in normal tissues is also quite different, mouse mdd Pgp and human MDR3 Pgp being predominantly expressed in the canalicular membrane of the hepatocyte, and to a lesser extent also in muscle and spleen (6-8). Their function remained obscure," @default.
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• W2049664564 date "1995-11-01" @default.
• W2049664564 modified "2023-09-26" @default.
• W2049664564 title "The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology" @default.
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• W2049664564 doi "https://doi.org/10.1016/0168-8278(95)80071-9" @default.
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