FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049665884> ?p ?o ?g. }

• W2049665884 endingPage "109" @default.
• W2049665884 startingPage "103" @default.
• W2049665884 abstract "Abstract— The fluorescence decay of the mutagenic drug proflavine (PF) bound to DNA at a phosphate‐to‐drug ratio of 420 is found to be a non‐exponential function of time. The deviation from exponentiality is shown to increase with increasing GC content of DNA. Thus, heterogeneity in the high affinity binding sites is clearly demonstrated. The nucleotides guanosine‐5‘‐monophosphate (GMP) and cyti‐dine‐5’‐monophosphate (CMP) are shown to form complexes with PF in 10 ‐3 M sodium cacodylate buffer at pH 6.6. In addition, GMP quenches substantially the fluorescence of PF while CMP enhances it slightly. The fluorescence decay curves for 5 × I0 ‐6 M PF in the presence of GMP concentrations greater than 10 ‐2 M exhibit a deviation from exponentiality which parallels that exhibited by the fluorescence decay curves for PF bound to DNA of increasing GC content. It is inferred that (a) guanine is responsible for the quenching of the fluorescence of PF on binding to DNA; and (b) the forces involved in the interaction between PF and DNA are specific in nature. The implications of these findings concerning the mutagenic properties of acridine derivatives are discussed. Nanosecond depolarization studies reveal a quite fast depolarization of the fluorescence of bound PF; for the PF‐ Cl. perfringens DNA complex the rotational correlation time is about 26 ns. Time‐resolved emission spectroscopy in the nanosecond scale demonstrates that, despite the change in the orientation of the drug, the electronic structure of the PF‐DNA complex is not substantially altered during the lifetime of the excited singlet electronic state of the drug." @default.
• W2049665884 created "2016-06-24" @default.
• W2049665884 creator A5019620765 @default.
• W2049665884 date "1975-09-01" @default.
• W2049665884 modified "2023-09-24" @default.
• W2049665884 title "ON THE NATURE OF INTERACTION BETWEEN PROFLAVINE and DNA" @default.
• W2049665884 cites W1968018789 @default.
• W2049665884 cites W1968223484 @default.
• W2049665884 cites W1985378108 @default.
• W2049665884 cites W1987890274 @default.
• W2049665884 cites W1992784057 @default.
• W2049665884 cites W1995707633 @default.
• W2049665884 cites W2012476052 @default.
• W2049665884 cites W2013544081 @default.
• W2049665884 cites W2037415484 @default.
• W2049665884 cites W2040756966 @default.
• W2049665884 cites W2050393990 @default.
• W2049665884 cites W2058982945 @default.
• W2049665884 cites W2060458798 @default.
• W2049665884 cites W2067878166 @default.
• W2049665884 cites W2067995665 @default.
• W2049665884 cites W2072557919 @default.
• W2049665884 cites W2074137787 @default.
• W2049665884 cites W2083051798 @default.
• W2049665884 cites W2145771605 @default.
• W2049665884 cites W2170681445 @default.
• W2049665884 cites W2249465159 @default.
• W2049665884 doi "https://doi.org/10.1111/j.1751-1097.1975.tb08820.x" @default.
• W2049665884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/172921" @default.
• W2049665884 hasPublicationYear "1975" @default.
• W2049665884 type Work @default.
• W2049665884 sameAs 2049665884 @default.
• W2049665884 citedByCount "48" @default.
• W2049665884 countsByYear W20496658842013 @default.
• W2049665884 countsByYear W20496658842015 @default.
• W2049665884 crossrefType "journal-article" @default.
• W2049665884 hasAuthorship W2049665884A5019620765 @default.
• W2049665884 hasConcept C104317684 @default.
• W2049665884 hasConcept C111357860 @default.
• W2049665884 hasConcept C113196181 @default.
• W2049665884 hasConcept C121332964 @default.
• W2049665884 hasConcept C121745418 @default.
• W2049665884 hasConcept C12554922 @default.
• W2049665884 hasConcept C185592680 @default.
• W2049665884 hasConcept C21463570 @default.
• W2049665884 hasConcept C2776594999 @default.
• W2049665884 hasConcept C2777995097 @default.
• W2049665884 hasConcept C2778301229 @default.
• W2049665884 hasConcept C4141045 @default.
• W2049665884 hasConcept C41625074 @default.
• W2049665884 hasConcept C43617362 @default.
• W2049665884 hasConcept C512185932 @default.
• W2049665884 hasConcept C552990157 @default.
• W2049665884 hasConcept C55493867 @default.
• W2049665884 hasConcept C62520636 @default.
• W2049665884 hasConcept C71240020 @default.
• W2049665884 hasConcept C8010536 @default.
• W2049665884 hasConcept C86803240 @default.
• W2049665884 hasConcept C91881484 @default.
• W2049665884 hasConceptScore W2049665884C104317684 @default.
• W2049665884 hasConceptScore W2049665884C111357860 @default.
• W2049665884 hasConceptScore W2049665884C113196181 @default.
• W2049665884 hasConceptScore W2049665884C121332964 @default.
• W2049665884 hasConceptScore W2049665884C121745418 @default.
• W2049665884 hasConceptScore W2049665884C12554922 @default.
• W2049665884 hasConceptScore W2049665884C185592680 @default.
• W2049665884 hasConceptScore W2049665884C21463570 @default.
• W2049665884 hasConceptScore W2049665884C2776594999 @default.
• W2049665884 hasConceptScore W2049665884C2777995097 @default.
• W2049665884 hasConceptScore W2049665884C2778301229 @default.
• W2049665884 hasConceptScore W2049665884C4141045 @default.
• W2049665884 hasConceptScore W2049665884C41625074 @default.
• W2049665884 hasConceptScore W2049665884C43617362 @default.
• W2049665884 hasConceptScore W2049665884C512185932 @default.
• W2049665884 hasConceptScore W2049665884C552990157 @default.
• W2049665884 hasConceptScore W2049665884C55493867 @default.
• W2049665884 hasConceptScore W2049665884C62520636 @default.
• W2049665884 hasConceptScore W2049665884C71240020 @default.
• W2049665884 hasConceptScore W2049665884C8010536 @default.
• W2049665884 hasConceptScore W2049665884C86803240 @default.
• W2049665884 hasConceptScore W2049665884C91881484 @default.
• W2049665884 hasIssue "3-4" @default.
• W2049665884 hasLocation W20496658841 @default.
• W2049665884 hasLocation W20496658842 @default.
• W2049665884 hasOpenAccess W2049665884 @default.
• W2049665884 hasPrimaryLocation W20496658841 @default.
• W2049665884 hasRelatedWork W1967443949 @default.
• W2049665884 hasRelatedWork W1983340804 @default.
• W2049665884 hasRelatedWork W1986654251 @default.
• W2049665884 hasRelatedWork W2028968466 @default.
• W2049665884 hasRelatedWork W2043187001 @default.
• W2049665884 hasRelatedWork W2194300488 @default.
• W2049665884 hasRelatedWork W2312601058 @default.
• W2049665884 hasRelatedWork W2332979485 @default.
• W2049665884 hasRelatedWork W2471444529 @default.
• W2049665884 hasRelatedWork W4313210395 @default.
• W2049665884 hasVolume "22" @default.
• W2049665884 isParatext "false" @default.

• next