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- W2049666918 abstract "The possibility of binding Concanavalin A containing liposomes to the intraocular tissues of the dogfish ( Mustelus canis ) eye was investigated both in vitro and in vivo. Whole fresh dogfish lenses incubated with liposome preparations were examined by fluorescence and scanning electron microscopy. Scanning electron microscopy and fluorescence microscopy demonstrated that liposomes containing Concanavalin A were bound to the lens capsule and that this binding was inhibited if lenses were preincubated with Concanavalin A. There was little non-specific binding of liposomes alone. In vivo, small volumes of aqueous humor were withdrawn from the eyes and were replaced with fluorescein-labelled Concanavalin A-containing liposomes in phosphate buffered saline. After 6 hr, fluorescence and scanning electron microscopy revealed liposomes bound only to the anterior lens capsule and to a lesser extent to the corneal endothelium. At 23 and 30 hr liposomes were demonstrable only on the anterior lens capsule. These findings suggest that lectin-mediated binding of liposomes to intraocular tissues may be used as a method for specific drug delivery to these tissues." @default.
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- W2049666918 date "1981-04-01" @default.
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- W2049666918 title "Lectin-mediated binding of liposomes to the ocular lens" @default.
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- W2049666918 doi "https://doi.org/10.1016/s0014-4835(81)80019-x" @default.
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