Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049668864> ?p ?o ?g. }
- W2049668864 endingPage "780" @default.
- W2049668864 startingPage "772" @default.
- W2049668864 abstract "Glycogen synthase kinase-3beta (GSK-3beta) has been proposed as the main kinase able to phosphorylate tau aberrantly in Alzheimer's disease and in related tauopathies. We have previously generated a double transgenic mouse line overexpressing the enzyme GSK-3beta and tau protein carrying a triple frontotemporal dementia and parkinsonism linked to chromosome 17 mutation whose expression patterns overlap in CA1 (pyramidal neurons) and dentate gyrus (granular neurons). Here, we have used this transgenic model to analyze how axonal and somatodendritic neuronal compartments are affected in the hippocampus. Our data demonstrate that neuronal subpopulations respond differentially to increased GSK-3 activity. Thus, dentate gyrus granular neurons undergo apoptotic death with subsequent degeneration of the mossy fibers, while CA1 pyramidal neurons accumulate hyperphosphorylated tau both in the axonal and in the somatodendritic compartments. These studies also allow us to propose a model of spreading of pathology through the hippocampus as a consequence of GSK-3 and tau dysregulation." @default.
- W2049668864 created "2016-06-24" @default.
- W2049668864 creator A5000788977 @default.
- W2049668864 creator A5019340831 @default.
- W2049668864 creator A5048049181 @default.
- W2049668864 creator A5063558026 @default.
- W2049668864 creator A5079838423 @default.
- W2049668864 creator A5084018006 @default.
- W2049668864 creator A5087593615 @default.
- W2049668864 date "2008-12-01" @default.
- W2049668864 modified "2023-10-17" @default.
- W2049668864 title "Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3β" @default.
- W2049668864 cites W126426573 @default.
- W2049668864 cites W1483825698 @default.
- W2049668864 cites W1611407165 @default.
- W2049668864 cites W1960647274 @default.
- W2049668864 cites W1982947429 @default.
- W2049668864 cites W1984453732 @default.
- W2049668864 cites W1985446830 @default.
- W2049668864 cites W1986537744 @default.
- W2049668864 cites W1991992154 @default.
- W2049668864 cites W1996917933 @default.
- W2049668864 cites W2003589106 @default.
- W2049668864 cites W2018423808 @default.
- W2049668864 cites W2018983416 @default.
- W2049668864 cites W2027331854 @default.
- W2049668864 cites W2030804652 @default.
- W2049668864 cites W2031102482 @default.
- W2049668864 cites W2031179697 @default.
- W2049668864 cites W2031864556 @default.
- W2049668864 cites W2039550162 @default.
- W2049668864 cites W2047364115 @default.
- W2049668864 cites W2058570072 @default.
- W2049668864 cites W2065961022 @default.
- W2049668864 cites W2067042124 @default.
- W2049668864 cites W2073292164 @default.
- W2049668864 cites W2077651746 @default.
- W2049668864 cites W2108177092 @default.
- W2049668864 cites W2114358785 @default.
- W2049668864 cites W2125904354 @default.
- W2049668864 cites W2135309154 @default.
- W2049668864 cites W2164136371 @default.
- W2049668864 cites W2168957011 @default.
- W2049668864 cites W2169063473 @default.
- W2049668864 cites W2171660142 @default.
- W2049668864 cites W2283169761 @default.
- W2049668864 doi "https://doi.org/10.1016/j.neuroscience.2008.09.047" @default.
- W2049668864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18951953" @default.
- W2049668864 hasPublicationYear "2008" @default.
- W2049668864 type Work @default.
- W2049668864 sameAs 2049668864 @default.
- W2049668864 citedByCount "8" @default.
- W2049668864 countsByYear W20496688642012 @default.
- W2049668864 countsByYear W20496688642014 @default.
- W2049668864 countsByYear W20496688642015 @default.
- W2049668864 countsByYear W20496688642019 @default.
- W2049668864 crossrefType "journal-article" @default.
- W2049668864 hasAuthorship W2049668864A5000788977 @default.
- W2049668864 hasAuthorship W2049668864A5019340831 @default.
- W2049668864 hasAuthorship W2049668864A5048049181 @default.
- W2049668864 hasAuthorship W2049668864A5063558026 @default.
- W2049668864 hasAuthorship W2049668864A5079838423 @default.
- W2049668864 hasAuthorship W2049668864A5084018006 @default.
- W2049668864 hasAuthorship W2049668864A5087593615 @default.
- W2049668864 hasConcept C102230213 @default.
- W2049668864 hasConcept C104317684 @default.
- W2049668864 hasConcept C104629339 @default.
- W2049668864 hasConcept C11960822 @default.
- W2049668864 hasConcept C141035611 @default.
- W2049668864 hasConcept C142724271 @default.
- W2049668864 hasConcept C148762608 @default.
- W2049668864 hasConcept C169760540 @default.
- W2049668864 hasConcept C182996813 @default.
- W2049668864 hasConcept C184235292 @default.
- W2049668864 hasConcept C192118531 @default.
- W2049668864 hasConcept C2776464000 @default.
- W2049668864 hasConcept C2776525014 @default.
- W2049668864 hasConcept C2778641062 @default.
- W2049668864 hasConcept C2778670691 @default.
- W2049668864 hasConcept C2779134260 @default.
- W2049668864 hasConcept C2779483572 @default.
- W2049668864 hasConcept C2781161787 @default.
- W2049668864 hasConcept C502032728 @default.
- W2049668864 hasConcept C55493867 @default.
- W2049668864 hasConcept C71924100 @default.
- W2049668864 hasConcept C86803240 @default.
- W2049668864 hasConcept C95444343 @default.
- W2049668864 hasConceptScore W2049668864C102230213 @default.
- W2049668864 hasConceptScore W2049668864C104317684 @default.
- W2049668864 hasConceptScore W2049668864C104629339 @default.
- W2049668864 hasConceptScore W2049668864C11960822 @default.
- W2049668864 hasConceptScore W2049668864C141035611 @default.
- W2049668864 hasConceptScore W2049668864C142724271 @default.
- W2049668864 hasConceptScore W2049668864C148762608 @default.
- W2049668864 hasConceptScore W2049668864C169760540 @default.
- W2049668864 hasConceptScore W2049668864C182996813 @default.
- W2049668864 hasConceptScore W2049668864C184235292 @default.
- W2049668864 hasConceptScore W2049668864C192118531 @default.