FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049670226> ?p ?o ?g. }

• W2049670226 endingPage "1700" @default.
• W2049670226 startingPage "1693" @default.
• W2049670226 abstract "To examine the potential role of high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of arthritis.Mice were injected intraarticularly with 1 microg or 5 microg of HMGB-1. Joints were dissected on days 4, 7, and 28 after injection and were evaluated histopathologically and immunohistochemically. To investigate the importance of different white blood cell populations for the development of arthritis, in vivo cell depletion procedures were performed. In addition, spleen cells were cultured in the presence of HMGB-1, and nuclear factor kappaB (NF-kappaB) activation was detected by electrophoretic mobility shift assay.Injection of recombinant HMGB-1 (rHMGB-1) into different mouse strains resulted in an overall frequency of arthritis in 80% of the animals. The inflammation was characterized by mild to moderate synovitis and lasted for at least 28 days. The majority of cells found in the inflamed synovium were Mac-1+ macrophages, whereas only a few CD4+ lymphocytes were detected. Pannus formation was observed in some cases 7 and 28 days after HMGB-1 injection. No significant differences were found with respect to incidence and severity of arthritis between mice depleted of monocytes, granulocytes, or lacking T/B lymphocytes. However, combined removal of monocytes and neutrophils resulted in a 43% lower incidence of arthritis. Mice rendered deficient in the interleukin-1 (IL-1) receptor did not develop inflammation upon challenge with HMGB-1. In vitro data corroborate this finding, showing that rHMGB-1 activated NF-kappaB, a major pathway leading to IL-1 production.Our results indicate that HMGB-1 is not a mere expression of inflammatory responses, but on its own, it triggers joint inflammation by activating macrophages and inducing production of IL-1 via NF-kappaB activation." @default.
• W2049670226 created "2016-06-24" @default.
• W2049670226 creator A5028731430 @default.
• W2049670226 creator A5060447636 @default.
• W2049670226 creator A5066540554 @default.
• W2049670226 creator A5075168559 @default.
• W2049670226 creator A5078542779 @default.
• W2049670226 creator A5082065959 @default.
• W2049670226 creator A5089318509 @default.
• W2049670226 date "2003-06-01" @default.
• W2049670226 modified "2023-10-01" @default.
• W2049670226 title "High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis" @default.
• W2049670226 cites W1547011386 @default.
• W2049670226 cites W1969826234 @default.
• W2049670226 cites W1972258963 @default.
• W2049670226 cites W1981559934 @default.
• W2049670226 cites W1999213416 @default.
• W2049670226 cites W2001822918 @default.
• W2049670226 cites W2005640704 @default.
• W2049670226 cites W2023318533 @default.
• W2049670226 cites W2026623381 @default.
• W2049670226 cites W2026885016 @default.
• W2049670226 cites W2047002683 @default.
• W2049670226 cites W2059217150 @default.
• W2049670226 cites W2065427271 @default.
• W2049670226 cites W2115293825 @default.
• W2049670226 cites W2128426645 @default.
• W2049670226 cites W2131757382 @default.
• W2049670226 cites W2146807706 @default.
• W2049670226 cites W2159416234 @default.
• W2049670226 cites W2161619169 @default.
• W2049670226 cites W2164714222 @default.
• W2049670226 cites W2168643298 @default.
• W2049670226 cites W2171028311 @default.
• W2049670226 cites W2171491673 @default.
• W2049670226 cites W2186856601 @default.
• W2049670226 cites W4295965450 @default.
• W2049670226 doi "https://doi.org/10.1002/art.11028" @default.
• W2049670226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12794838" @default.
• W2049670226 hasPublicationYear "2003" @default.
• W2049670226 type Work @default.
• W2049670226 sameAs 2049670226 @default.
• W2049670226 citedByCount "177" @default.
• W2049670226 countsByYear W20496702262012 @default.
• W2049670226 countsByYear W20496702262013 @default.
• W2049670226 countsByYear W20496702262014 @default.
• W2049670226 countsByYear W20496702262015 @default.
• W2049670226 countsByYear W20496702262016 @default.
• W2049670226 countsByYear W20496702262017 @default.
• W2049670226 countsByYear W20496702262018 @default.
• W2049670226 countsByYear W20496702262019 @default.
• W2049670226 countsByYear W20496702262020 @default.
• W2049670226 countsByYear W20496702262021 @default.
• W2049670226 countsByYear W20496702262022 @default.
• W2049670226 countsByYear W20496702262023 @default.
• W2049670226 crossrefType "journal-article" @default.
• W2049670226 hasAuthorship W2049670226A5028731430 @default.
• W2049670226 hasAuthorship W2049670226A5060447636 @default.
• W2049670226 hasAuthorship W2049670226A5066540554 @default.
• W2049670226 hasAuthorship W2049670226A5075168559 @default.
• W2049670226 hasAuthorship W2049670226A5078542779 @default.
• W2049670226 hasAuthorship W2049670226A5082065959 @default.
• W2049670226 hasAuthorship W2049670226A5089318509 @default.
• W2049670226 hasConcept C126322002 @default.
• W2049670226 hasConcept C203014093 @default.
• W2049670226 hasConcept C2776914184 @default.
• W2049670226 hasConcept C2777077863 @default.
• W2049670226 hasConcept C2778488018 @default.
• W2049670226 hasConcept C2778690821 @default.
• W2049670226 hasConcept C2779244835 @default.
• W2049670226 hasConcept C2780942790 @default.
• W2049670226 hasConcept C71924100 @default.
• W2049670226 hasConceptScore W2049670226C126322002 @default.
• W2049670226 hasConceptScore W2049670226C203014093 @default.
• W2049670226 hasConceptScore W2049670226C2776914184 @default.
• W2049670226 hasConceptScore W2049670226C2777077863 @default.
• W2049670226 hasConceptScore W2049670226C2778488018 @default.
• W2049670226 hasConceptScore W2049670226C2778690821 @default.
• W2049670226 hasConceptScore W2049670226C2779244835 @default.
• W2049670226 hasConceptScore W2049670226C2780942790 @default.
• W2049670226 hasConceptScore W2049670226C71924100 @default.
• W2049670226 hasIssue "6" @default.
• W2049670226 hasLocation W20496702261 @default.
• W2049670226 hasLocation W20496702262 @default.
• W2049670226 hasOpenAccess W2049670226 @default.
• W2049670226 hasPrimaryLocation W20496702261 @default.
• W2049670226 hasRelatedWork W2016849635 @default.
• W2049670226 hasRelatedWork W2018684240 @default.
• W2049670226 hasRelatedWork W2033838615 @default.
• W2049670226 hasRelatedWork W2056067227 @default.
• W2049670226 hasRelatedWork W2082589947 @default.
• W2049670226 hasRelatedWork W2186316345 @default.
• W2049670226 hasRelatedWork W2324533107 @default.
• W2049670226 hasRelatedWork W2370370936 @default.
• W2049670226 hasRelatedWork W3030951269 @default.
• W2049670226 hasRelatedWork W4248746885 @default.
• W2049670226 hasVolume "48" @default.
• W2049670226 isParatext "false" @default.

• next