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• W2049672012 abstract "Following our previous demonstration that p,p ′-DDE (dichlorodiphenylchloroethylene), at environmentally relevant concentrations, can rapidly increase intracellular calcium [Ca 2+ ] i concentrations in human granulosa-lutein cells, we examined whether other pesticides, such as Kepone, o,p -DDE and methoxychlor, have similar effects. Cultured human granulosa-lutein cells were loaded with Fura-2 AM, and changes in [Ca 2+ ] i concentrations within small areas of single cells were studied with a dynamic digital Ca 2+ imaging system. Kepone, at concentrations of 0.2–2 nmol/ml, consistently increased [Ca 2+ ] i concentrations 2–6 times higher than baseline values within minutes of exposure. Methoxychlor at concentrations of 2.8–280 nmol/ml failed to alter [Ca 2+ ] i levels consistently in cells from 10 patients. However, at 0.28 and 1.4 nmol/ml, increases in [Ca 2+ ] i concentrations could be elicited by methoxychlor. The isomer o,p -DDE at 3 nmol/ml increased [Ca 2+ ] i in granulosa cells of 11/20 patients. Pertussis toxin treatment inhibited the [Ca 2+ ] i increases induced by estradiol, p,p ′-DDE, o,p -DDE and methoxychlor, but not by Kepone or progesterone, indicating that Kepone and progesterone may act through an insensitive G protein-coupled receptor. The [Ca 2+ ] i increases induced by Kepone also occurred in Ca 2+ -free medium, suggesting that [Ca 2+ ] i mobilization occurred from the smooth endoplasmic reticulum. Thapsigargin and cyclopiazonic acid, two inhibitors of the endoplasmic reticulum Ca 2+ pump, also stimulated [Ca 2+ ] i increases but did not inhibit the Ca 2+ response to all the pesticides. These results demonstrate that pesticides can have a rapid effect on human granulosa-lutein cells, and a nongenomic mechanism of action is suggested" @default.
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• W2049672012 date "2006-02-01" @default.
• W2049672012 modified "2023-09-27" @default.
• W2049672012 title "Rapid effects of pesticides on human granulosa-lutein cells" @default.
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• W2049672012 doi "https://doi.org/10.1530/rep.1.00922" @default.
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