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- W2049672023 abstract "Abstract The highly purified, crystalline conjugated bile salts glycocholate and taurocholate at 8 mM did not affect: (1) the transport of glucose, sorbose, urea, lysine, leucine, acetate and sodium across perfused segments of rat jejunum; (2) the incorporation of leucine and lysine into protein, or of acetate into lipid by perfused jejunal segments; or (3) the uptake of oxygen and the conversion of glucose into triglyceride by jejunal rings. However, they did inhibit adenosine triphosphate activity of jejunal mucosal homogenates and brush border preparations, and at 4 mM significantly decreased the P:O ratios of respiring liver mitochondria. Deoxycholate, a common contaminant of conjugated bile salt preparations, at 0.4 mM inhibited the transport of all substances examined, except sorbose, and depressed the other metabolic functions studied. Cholate was a weaker inhibitor than deoxycholate. Longchain fatty acids, another common contaminant of bile salt preparations, caused an increased incorporation of glucose into triglyceride. Thus previous reports that conjugated bile salts stimulate or inhibit the absorption or intracellular metabolism of water-soluble nutrients by the gut may well have resulted from contamination of the bile salt preparations with deoxycholate or fatty acids." @default.
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- W2049672023 date "1966-11-01" @default.
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- W2049672023 title "Action of bile salts on the metabolism and transport of water-soluble nutrients by perfused rat jejunum in vitro★" @default.
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