FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049673631> ?p ?o ?g. }

• W2049673631 abstract "A neurotoxic phospholipase A2 was purified from the venom of the taipan snake Oxyuranus scutellatus scutellatus by three consecutive chromatographic steps on ion exchange resins, followed by an affinity column prepared with a phosphatidylcholine derivative attached to Sepharose. The phospholipase was shown to be of type A2 (specific activity of 85 units/mg protein), and an apparent molecular weight of 16,000. Amino acid analysis shows the presence of approx. 150 residues with the N-terminal amino acid sequence: NLAQFGFMIRCANGGSRSALDYADYGC, different from all the phospholipases described until now. This enzyme is lethal to experimental mice (LD50 = 10 micrograms/20 g mouse weight) and affects ionic currents in chick (Gallus domesticus) dorsal root ganglion cells, measured by the whole-cell clamp technique. In symmetrical external/internal ionic solutions, after suppression of Na+, K+ and Ca2+ currents, external application of phospholipase at a low concentration (30 nM) was shown to increase the baseline current in a reversible manner. The augmented response was voltage-dependent and the effect was much greater for negative currents. In the presence of a salt gradient across the membrane (out 40 mM NaCl/in 140 mM CsCl), the current reversal potential revealed a shift in the positive direction typically due to Cl- ion flux through the membrane. External application of a 50 microM concentration of picrotoxin caused a reversible reduction of the phospholipase-induced chloride current. Moreover, no appreciable current block was detected after addition of 50 microM DIDS." @default.
• W2049673631 created "2016-06-24" @default.
• W2049673631 creator A5011982670 @default.
• W2049673631 creator A5016486857 @default.
• W2049673631 creator A5032759906 @default.
• W2049673631 creator A5038559219 @default.
• W2049673631 creator A5072898786 @default.
• W2049673631 creator A5090538774 @default.
• W2049673631 date "1992-04-01" @default.
• W2049673631 modified "2023-09-27" @default.
• W2049673631 title "Anionic currents of chick sensory neurons are affected by a phospholipase A2 purified from the venom of the taipan snake" @default.
• W2049673631 cites W1514236298 @default.
• W2049673631 cites W1536772199 @default.
• W2049673631 cites W1579677476 @default.
• W2049673631 cites W1762550845 @default.
• W2049673631 cites W1967647423 @default.
• W2049673631 cites W1973471035 @default.
• W2049673631 cites W1988788901 @default.
• W2049673631 cites W1993472665 @default.
• W2049673631 cites W1999720041 @default.
• W2049673631 cites W2001842787 @default.
• W2049673631 cites W2008061474 @default.
• W2049673631 cites W2009667219 @default.
• W2049673631 cites W2013587333 @default.
• W2049673631 cites W2014734875 @default.
• W2049673631 cites W2014992401 @default.
• W2049673631 cites W2023638493 @default.
• W2049673631 cites W2028205995 @default.
• W2049673631 cites W2031255598 @default.
• W2049673631 cites W2032588094 @default.
• W2049673631 cites W2039084809 @default.
• W2049673631 cites W2047912256 @default.
• W2049673631 cites W2050335943 @default.
• W2049673631 cites W2053892418 @default.
• W2049673631 cites W2056164265 @default.
• W2049673631 cites W2081182987 @default.
• W2049673631 cites W2085474307 @default.
• W2049673631 cites W2086253122 @default.
• W2049673631 cites W2089843271 @default.
• W2049673631 cites W2092596494 @default.
• W2049673631 cites W2100837269 @default.
• W2049673631 cites W2102262193 @default.
• W2049673631 cites W2103080446 @default.
• W2049673631 cites W2105997907 @default.
• W2049673631 cites W2113301876 @default.
• W2049673631 cites W2116304547 @default.
• W2049673631 cites W2172962186 @default.
• W2049673631 cites W2328734883 @default.
• W2049673631 cites W4241508277 @default.
• W2049673631 cites W979425508 @default.
• W2049673631 doi "https://doi.org/10.1016/0167-4889(92)90178-e" @default.
• W2049673631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1373076" @default.
• W2049673631 hasPublicationYear "1992" @default.
• W2049673631 type Work @default.
• W2049673631 sameAs 2049673631 @default.
• W2049673631 citedByCount "5" @default.
• W2049673631 crossrefType "journal-article" @default.
• W2049673631 hasAuthorship W2049673631A5011982670 @default.
• W2049673631 hasAuthorship W2049673631A5016486857 @default.
• W2049673631 hasAuthorship W2049673631A5032759906 @default.
• W2049673631 hasAuthorship W2049673631A5038559219 @default.
• W2049673631 hasAuthorship W2049673631A5072898786 @default.
• W2049673631 hasAuthorship W2049673631A5090538774 @default.
• W2049673631 hasConcept C12554922 @default.
• W2049673631 hasConcept C12927208 @default.
• W2049673631 hasConcept C181199279 @default.
• W2049673631 hasConcept C185592680 @default.
• W2049673631 hasConcept C2776330855 @default.
• W2049673631 hasConcept C2776551241 @default.
• W2049673631 hasConcept C2776888444 @default.
• W2049673631 hasConcept C2778597717 @default.
• W2049673631 hasConcept C2778918659 @default.
• W2049673631 hasConcept C2779448229 @default.
• W2049673631 hasConcept C2779533339 @default.
• W2049673631 hasConcept C41625074 @default.
• W2049673631 hasConcept C43617362 @default.
• W2049673631 hasConcept C55493867 @default.
• W2049673631 hasConcept C86803240 @default.
• W2049673631 hasConceptScore W2049673631C12554922 @default.
• W2049673631 hasConceptScore W2049673631C12927208 @default.
• W2049673631 hasConceptScore W2049673631C181199279 @default.
• W2049673631 hasConceptScore W2049673631C185592680 @default.
• W2049673631 hasConceptScore W2049673631C2776330855 @default.
• W2049673631 hasConceptScore W2049673631C2776551241 @default.
• W2049673631 hasConceptScore W2049673631C2776888444 @default.
• W2049673631 hasConceptScore W2049673631C2778597717 @default.
• W2049673631 hasConceptScore W2049673631C2778918659 @default.
• W2049673631 hasConceptScore W2049673631C2779448229 @default.
• W2049673631 hasConceptScore W2049673631C2779533339 @default.
• W2049673631 hasConceptScore W2049673631C41625074 @default.
• W2049673631 hasConceptScore W2049673631C43617362 @default.
• W2049673631 hasConceptScore W2049673631C55493867 @default.
• W2049673631 hasConceptScore W2049673631C86803240 @default.
• W2049673631 hasLocation W20496736311 @default.
• W2049673631 hasLocation W20496736312 @default.
• W2049673631 hasOpenAccess W2049673631 @default.
• W2049673631 hasPrimaryLocation W20496736311 @default.
• W2049673631 hasRelatedWork W1485550458 @default.
• W2049673631 hasRelatedWork W1819161614 @default.
• W2049673631 hasRelatedWork W1879668707 @default.

• next