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- W2049697118 abstract "Inflammatory malignant fibrous histiocytoma (IMFH) is composed of fibroblastic and histiocytic elements with a marked inflammatory cell infiltrate. The authors examined the case of a 43-year-old woman with IMFH of the ovary.The serum interleukin-6 (IL-6) levels were examined and immunohistochemical analysis of the tumor was performed using monoclonal antibodies against lysozyme, alpha 1-antitripsin, vimentin, and IL-6.The patient had marked general inflammatory reactions of fever (38.0 degrees C), leukocytosis with 78.3% neutrophils, elevated CRP (23.5 mg/dl), and accelerated ESR (166 mm/h). The serum IL-6 concentration was 499 pg/ml. The right ovary was occupied by the solid tumor, composed of both fibrous and histiocytic elements with a marked inflammatory cell infiltrate. These inflammatory reactions disappeared after surgical resection and recurred when the tumor reappeared. The immunohistochemical staining of lysozyme, alpha 1-antitrypsin, vimentin, and IL-6 was localized to the malignant cells, suggesting their histiocytic origin.This is the first case of IMFH of the ovary producing IL-6. Expression of IL-6 in the IMFH may account for both the local and the systemic inflammatory effects of tumors with these morphological features." @default.
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- W2049697118 date "1999-12-01" @default.
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- W2049697118 title "Inflammatory Malignant Fibrous Histiocytoma of the Ovary Producing Interleukin-6: A Case Report" @default.
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- W2049697118 doi "https://doi.org/10.1006/gyno.1999.5589" @default.
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