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• W2049702012 abstract "High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliver functional microRNAs (miRNA). Here we show that HDL suppresses expression of intercellular adhesion molecule 1 (ICAM-1) through the transfer of miR-223 to endothelial cells. After incubation of endothelial cells with HDL, mature miR-223 levels are significantly increased in endothelial cells and decreased on HDL. However, miR-223 is not transcribed in endothelial cells and is not increased in cells treated with HDL from miR-223(-/-) mice. HDL inhibit ICAM-1 protein levels, but not in cells pretreated with miR-223 inhibitors. ICAM-1 is a direct target of HDL-transferred miR-223 and this is the first example of an extracellular miRNA regulating gene expression in cells where it is not transcribed. Collectively, we demonstrate that HDL's anti-inflammatory properties are conferred, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells." @default.
• W2049702012 created "2016-06-24" @default.
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• W2049702012 date "2014-02-28" @default.
• W2049702012 modified "2023-10-17" @default.
• W2049702012 title "HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells" @default.
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• W2049702012 doi "https://doi.org/10.1038/ncomms4292" @default.
• W2049702012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4189962" @default.
• W2049702012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24576947" @default.
• W2049702012 hasPublicationYear "2014" @default.
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