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- W2049717738 endingPage "984" @default.
- W2049717738 startingPage "963" @default.
- W2049717738 abstract "The purpose of this article is to identify core technologies with the potential to influence the development of thin-layer chromatography over the next decade or so. Core technologies are identified as: (i) methods to provide a constant and optimum mobile phase velocity (forced flow and electroosmotically-driven flow), (ii) video densitometry for recording multidimensional chromatograms, (iii) in situ scanning mass spectrometry, and (iv) bioactivity monitoring for selective detection. In combination with two-dimensional, multiple development and coupled column–layer separation techniques these core technologies could dramatically increase the use of thin-layer chromatography for the characterization of complex mixtures. It is also demonstrated that thin-layer chromatography has strong potential as a surrogate chromatographic model for estimating biopartitioning properties. To convert these opportunities into practice the current state-of-the-art of the core technologies is described and the principle obstacles to progress identified." @default.
- W2049717738 created "2016-06-24" @default.
- W2049717738 creator A5042984744 @default.
- W2049717738 date "2003-06-01" @default.
- W2049717738 modified "2023-10-11" @default.
- W2049717738 title "Thin-layer chromatography: challenges and opportunities" @default.
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