Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049718171> ?p ?o ?g. }
- W2049718171 endingPage "529" @default.
- W2049718171 startingPage "521" @default.
- W2049718171 abstract "Abstract Removal of β2‐microglobulin (β2M) from the blood of patients suffering from kidney dysfunction is crucial to protect those individuals from getting the diseased state of dialysis‐related amyloidosis. By harnessing the nucleation‐dependent fibrillation process of amyloidogenesis, a β2M removal strategy has been proposed by preparing seed‐conjugated polymer beads and assimilating soluble β2M to the fibrils on the surface at neutral pH. A novel peptide segment of β2M ranging from residue 58 to residue 67 (Lys‐Asp‐Trp‐Ser‐Phe‐Tyr‐Leu‐Leu‐Tyr‐Tyr), which was capable of being fibrillated at neutral pH was isolated. Charge interaction between the positive N‐terminal lysine and the negative C‐terminal α‐carboxylic group was demonstrated to be critical for the molecular self‐assembly leading to the peptide fibril formation by favoring β‐sheet conformation. Because the peptide fibrils were successful to seed intact β2M at neutral pH, the fibrils were immobilized on polymer beads of HiCore resins, and the resulting seed‐conjugated beads were used to accrete intact β2M in the form of fibrils elongated on the bead surface. Its efficiency of the β2M removal was improved by placing the seed‐immobilized beads in the middle of a continuous flow of the β2M‐containing solution as practiced in the blood circulation during the hemodialysis. Therefore, this β2M removal system is suggested to exhibit high specificity, high binding capacity, and cost‐effectiveness appropriate for eventual clinical application to remove β2M from the blood of renal failure patients. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011" @default.
- W2049718171 created "2016-06-24" @default.
- W2049718171 creator A5000129082 @default.
- W2049718171 creator A5003311318 @default.
- W2049718171 creator A5019207623 @default.
- W2049718171 creator A5040566713 @default.
- W2049718171 creator A5049872669 @default.
- W2049718171 creator A5053222940 @default.
- W2049718171 creator A5080786456 @default.
- W2049718171 creator A5067782923 @default.
- W2049718171 date "2011-03-01" @default.
- W2049718171 modified "2023-10-16" @default.
- W2049718171 title "Removal of intact β2-microglobulin at neutral ph by using seed-conjugated polymer beads prepared with β2-microglobulin-derived peptide (58-67)" @default.
- W2049718171 cites W123436181 @default.
- W2049718171 cites W1507265719 @default.
- W2049718171 cites W1589829200 @default.
- W2049718171 cites W1965753785 @default.
- W2049718171 cites W1965917973 @default.
- W2049718171 cites W1967733770 @default.
- W2049718171 cites W1970212015 @default.
- W2049718171 cites W1973897761 @default.
- W2049718171 cites W1980956914 @default.
- W2049718171 cites W1981466014 @default.
- W2049718171 cites W1981997035 @default.
- W2049718171 cites W1985381306 @default.
- W2049718171 cites W1985777259 @default.
- W2049718171 cites W1990287007 @default.
- W2049718171 cites W1990332976 @default.
- W2049718171 cites W1992655067 @default.
- W2049718171 cites W2008846886 @default.
- W2049718171 cites W2009890105 @default.
- W2049718171 cites W2011281728 @default.
- W2049718171 cites W2011977819 @default.
- W2049718171 cites W2017039845 @default.
- W2049718171 cites W2021673459 @default.
- W2049718171 cites W2022600793 @default.
- W2049718171 cites W2026832725 @default.
- W2049718171 cites W2027435002 @default.
- W2049718171 cites W2027839322 @default.
- W2049718171 cites W2028141811 @default.
- W2049718171 cites W2031253177 @default.
- W2049718171 cites W2032854254 @default.
- W2049718171 cites W2034057547 @default.
- W2049718171 cites W2039895804 @default.
- W2049718171 cites W2042848482 @default.
- W2049718171 cites W2044713016 @default.
- W2049718171 cites W2054498786 @default.
- W2049718171 cites W2060883541 @default.
- W2049718171 cites W2068230152 @default.
- W2049718171 cites W2070751693 @default.
- W2049718171 cites W2072246539 @default.
- W2049718171 cites W2073621332 @default.
- W2049718171 cites W2076532980 @default.
- W2049718171 cites W2083133391 @default.
- W2049718171 cites W2089563915 @default.
- W2049718171 cites W2089614129 @default.
- W2049718171 cites W2095854468 @default.
- W2049718171 cites W2099028937 @default.
- W2049718171 cites W2104571730 @default.
- W2049718171 cites W2106149319 @default.
- W2049718171 cites W2108008815 @default.
- W2049718171 cites W2111441225 @default.
- W2049718171 cites W2115851784 @default.
- W2049718171 cites W2116516653 @default.
- W2049718171 cites W2117481096 @default.
- W2049718171 cites W2129934571 @default.
- W2049718171 cites W2130410401 @default.
- W2049718171 cites W2131609927 @default.
- W2049718171 cites W2138903917 @default.
- W2049718171 cites W2140299175 @default.
- W2049718171 cites W2141662832 @default.
- W2049718171 cites W2154617974 @default.
- W2049718171 cites W2162575609 @default.
- W2049718171 cites W2166067983 @default.
- W2049718171 cites W23023949 @default.
- W2049718171 doi "https://doi.org/10.1002/btpr.562" @default.
- W2049718171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21365783" @default.
- W2049718171 hasPublicationYear "2011" @default.
- W2049718171 type Work @default.
- W2049718171 sameAs 2049718171 @default.
- W2049718171 citedByCount "8" @default.
- W2049718171 countsByYear W20497181712012 @default.
- W2049718171 countsByYear W20497181712015 @default.
- W2049718171 countsByYear W20497181712018 @default.
- W2049718171 countsByYear W20497181712019 @default.
- W2049718171 countsByYear W20497181712021 @default.
- W2049718171 countsByYear W20497181712023 @default.
- W2049718171 crossrefType "journal-article" @default.
- W2049718171 hasAuthorship W2049718171A5000129082 @default.
- W2049718171 hasAuthorship W2049718171A5003311318 @default.
- W2049718171 hasAuthorship W2049718171A5019207623 @default.
- W2049718171 hasAuthorship W2049718171A5040566713 @default.
- W2049718171 hasAuthorship W2049718171A5049872669 @default.
- W2049718171 hasAuthorship W2049718171A5053222940 @default.
- W2049718171 hasAuthorship W2049718171A5067782923 @default.
- W2049718171 hasAuthorship W2049718171A5080786456 @default.
- W2049718171 hasConcept C112613896 @default.
- W2049718171 hasConcept C12554922 @default.