FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049718696> ?p ?o ?g. }

• W2049718696 endingPage "194" @default.
• W2049718696 startingPage "187" @default.
• W2049718696 abstract "In the presence of magnesium, enolase catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to phosphoenolpyruvate (PEP) in glycolysis and the reverse reaction in gluconeogensis at comparable rates. The structure of human neuron specific enolase (hNSE) crystals soaked in PGA showed that the enzyme is active in the crystals and produced PEP; conversely soaking in PEP produced PGA. Moreover, the hNSE dimer contains PGA bound in one subunit and PEP or a mixture of PEP and PGA in the other. Crystals soaked in a mixture of competitive inhibitors tartronate semialdehyde phosphate (TSP) and lactic acid phosphate (LAP) showed asymmetry with TSP binding in the same site as PGA and LAP in the PEP site. Kinetic studies showed that the inhibition of NSE by mixtures of TSP and LAP is stronger than predicted for independently acting inhibitors. This indicates that in some cases inhibition of homodimeric enzymes by mixtures of inhibitors (“heteroinhibition”) may offer advantages over single inhibitors." @default.
• W2049718696 created "2016-06-24" @default.
• W2049718696 creator A5020266474 @default.
• W2049718696 creator A5039895393 @default.
• W2049718696 creator A5048918898 @default.
• W2049718696 creator A5075038023 @default.
• W2049718696 creator A5081693942 @default.
• W2049718696 date "2012-06-01" @default.
• W2049718696 modified "2023-10-16" @default.
• W2049718696 title "Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity" @default.
• W2049718696 cites W1513182170 @default.
• W2049718696 cites W1539796472 @default.
• W2049718696 cites W1710565104 @default.
• W2049718696 cites W1963572590 @default.
• W2049718696 cites W1964275052 @default.
• W2049718696 cites W1975243750 @default.
• W2049718696 cites W1979941255 @default.
• W2049718696 cites W1981975492 @default.
• W2049718696 cites W1986191025 @default.
• W2049718696 cites W1987418223 @default.
• W2049718696 cites W1992254836 @default.
• W2049718696 cites W1998093640 @default.
• W2049718696 cites W2003282365 @default.
• W2049718696 cites W2009105611 @default.
• W2049718696 cites W2015152681 @default.
• W2049718696 cites W2022572991 @default.
• W2049718696 cites W2023454927 @default.
• W2049718696 cites W2029086730 @default.
• W2049718696 cites W2032494141 @default.
• W2049718696 cites W2046786857 @default.
• W2049718696 cites W2061057944 @default.
• W2049718696 cites W2068340340 @default.
• W2049718696 cites W2073033441 @default.
• W2049718696 cites W2080722333 @default.
• W2049718696 cites W2084377671 @default.
• W2049718696 cites W2100273026 @default.
• W2049718696 cites W2140261762 @default.
• W2049718696 cites W2176990597 @default.
• W2049718696 cites W3118440386 @default.
• W2049718696 cites W4230158786 @default.
• W2049718696 cites W65288938 @default.
• W2049718696 cites W91085156 @default.
• W2049718696 doi "https://doi.org/10.1016/j.jinorgbio.2012.02.011" @default.
• W2049718696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3371154" @default.
• W2049718696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22437160" @default.
• W2049718696 hasPublicationYear "2012" @default.
• W2049718696 type Work @default.
• W2049718696 sameAs 2049718696 @default.
• W2049718696 citedByCount "24" @default.
• W2049718696 countsByYear W20497186962014 @default.
• W2049718696 countsByYear W20497186962015 @default.
• W2049718696 countsByYear W20497186962016 @default.
• W2049718696 countsByYear W20497186962017 @default.
• W2049718696 countsByYear W20497186962018 @default.
• W2049718696 countsByYear W20497186962019 @default.
• W2049718696 countsByYear W20497186962021 @default.
• W2049718696 countsByYear W20497186962022 @default.
• W2049718696 countsByYear W20497186962023 @default.
• W2049718696 crossrefType "journal-article" @default.
• W2049718696 hasAuthorship W2049718696A5020266474 @default.
• W2049718696 hasAuthorship W2049718696A5039895393 @default.
• W2049718696 hasAuthorship W2049718696A5048918898 @default.
• W2049718696 hasAuthorship W2049718696A5075038023 @default.
• W2049718696 hasAuthorship W2049718696A5081693942 @default.
• W2049718696 hasBestOaLocation W20497186962 @default.
• W2049718696 hasConcept C104292427 @default.
• W2049718696 hasConcept C104317684 @default.
• W2049718696 hasConcept C111368507 @default.
• W2049718696 hasConcept C121332964 @default.
• W2049718696 hasConcept C126322002 @default.
• W2049718696 hasConcept C127313418 @default.
• W2049718696 hasConcept C143937172 @default.
• W2049718696 hasConcept C148898269 @default.
• W2049718696 hasConcept C150757390 @default.
• W2049718696 hasConcept C166014724 @default.
• W2049718696 hasConcept C178790620 @default.
• W2049718696 hasConcept C181199279 @default.
• W2049718696 hasConcept C185592680 @default.
• W2049718696 hasConcept C187250156 @default.
• W2049718696 hasConcept C188618488 @default.
• W2049718696 hasConcept C204232928 @default.
• W2049718696 hasConcept C2777289219 @default.
• W2049718696 hasConcept C2779546866 @default.
• W2049718696 hasConcept C2780434155 @default.
• W2049718696 hasConcept C41183919 @default.
• W2049718696 hasConcept C55493867 @default.
• W2049718696 hasConcept C62520636 @default.
• W2049718696 hasConcept C71240020 @default.
• W2049718696 hasConcept C71924100 @default.
• W2049718696 hasConcept C8010536 @default.
• W2049718696 hasConcept C86756495 @default.
• W2049718696 hasConceptScore W2049718696C104292427 @default.
• W2049718696 hasConceptScore W2049718696C104317684 @default.
• W2049718696 hasConceptScore W2049718696C111368507 @default.
• W2049718696 hasConceptScore W2049718696C121332964 @default.
• W2049718696 hasConceptScore W2049718696C126322002 @default.
• W2049718696 hasConceptScore W2049718696C127313418 @default.
• W2049718696 hasConceptScore W2049718696C143937172 @default.

• next