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• W2049753406 abstract "Purpose We sought to determine whether filtering surgery, even when only partially successful, delays or slows visual field (VF) progression. Methods The records of all patients seen in a glaucoma referral practice from 1999 to 2009 were reviewed. Group A comprised eyes with ≥5 VFs before surgery and group B comprised eyes with ≥5 VFs after surgery. Eyes in group B were further divided into those requiring postoperative topical ocular hypotensive therapy (group B-2) and those that did not (group B-1). Automated pointwise linear regression was used to determine global rates (dB/y) of change and progression endpoints. A progression endpoint was determined when 2 or more adjacent test locations in the same hemifield showed a threshold sensitivity decline at a rate of ≥1.0 dB/year with P<0.01. Results A total of 206 treated eyes (206 patients; mean age, 63.8±13.0 y; 11.3±3.1 VFs; 6.4±1.8 y follow-up) were included. Mean global VF progression rates in group A (−0.86±0.8 dB/y) were faster than those in group B (−0.49±0.9 dB/y, P<0.01). Group A also had a greater risk of reaching a progression endpoint compared with group B (odds ratio=2.41, P<0.01). Groups B-1 and B-2 had different follow-up intraocular pressure means (12.7±3.7 vs. 15.5±2.7 mm Hg, respectively; P<0.01) and peaks (19.4±5.2 vs. 21.2±4.2 mm Hg; P=0.08). The velocity of VF progression was similar for groups B-1 and B-2 (−0.40±0.6 vs. −0.58±1.1 dB/y; P=0.22) and there was no significant difference between the 2 groups regarding the risk of reaching a progression endpoint (odds ratio=0.83, P=0.62). Conclusions Filtering surgery reduces the rate of disease progression and this effect persists even if adjunctive glaucoma medical therapy is required." @default.
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• W2049753406 date "2012-12-01" @default.
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• W2049753406 title "Effect of Successful and Partly Successful Filtering Surgery on the Velocity of Glaucomatous Visual Field Progression" @default.
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• W2049753406 doi "https://doi.org/10.1097/ijg.0b013e31821db409" @default.
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