FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049759397> ?p ?o ?g. }

• W2049759397 endingPage "1965" @default.
• W2049759397 startingPage "1958" @default.
• W2049759397 abstract "Lipoprotein(a) consists of a low-density lipoprotein containing apolipoprotein (apo) B-100 and of the genetically polymorphic apo(a). It is not known where and how lipoprotein(a) is assembled and whether there exists a precursor for lipoprotein(a). We have determined the phenotype, concentration, and distribution of apo(a) in plasma from patients with lipoprotein lipase (LPL) deficiency (type I hyperlipoproteinemia, n = 14), in apo E 2/2 homozygotes with type III hyperlipoproteinemia (n = 12) and in controls (n = 16). In the two genetic conditions, there is grossly impaired catabolic conversion of apo B-100-containing precursor lipoproteins to low-density lipoproteins. Considering apo(a) type, the plasma concentration of apo(a) was normal in type III patients but significantly reduced in LPL deficiency. Despite the defects in the catabolism of other apo B-containing lipoproteins, the distribution of apo(a) was only moderately affected in both metabolic disorders, with 66.7% (type I) and 74.7% (type III) being present as the characteristic lipoprotein(a) in the density range of 1.05-1.125 g/ml (controls 81.6%). The remainder was distributed between the triglyceride-rich lipoproteins (type I 12.4%, type III 8.5%, controls 4.7%) and the lipid-poor bottom fraction (type I 19.3%, type III 15.3%, controls 12.6%). In all conditions most apo(a) (57-88%) dissociated from the triglyceride-rich lipoproteins upon recentrifugation and was recovered as lipoprotein(a). These data suggest that lipoprotein(a) is not generated from a triglyceride-rich precursor. Lipoprotein(a) may be secreted directly into plasma or may be formed by preferential binding of secreted apo(a) to existing low-density lipoprotein." @default.
• W2049759397 created "2016-06-24" @default.
• W2049759397 creator A5044848732 @default.
• W2049759397 creator A5047572291 @default.
• W2049759397 creator A5056429133 @default.
• W2049759397 creator A5087893023 @default.
• W2049759397 date "1992-11-01" @default.
• W2049759397 modified "2023-10-17" @default.
• W2049759397 title "Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a)." @default.
• W2049759397 cites W113542706 @default.
• W2049759397 cites W1491117599 @default.
• W2049759397 cites W1501146982 @default.
• W2049759397 cites W1508982793 @default.
• W2049759397 cites W1523148876 @default.
• W2049759397 cites W1564079839 @default.
• W2049759397 cites W1573051637 @default.
• W2049759397 cites W1643136010 @default.
• W2049759397 cites W1964539644 @default.
• W2049759397 cites W1970055375 @default.
• W2049759397 cites W1973135952 @default.
• W2049759397 cites W1985025463 @default.
• W2049759397 cites W1985099812 @default.
• W2049759397 cites W1986030167 @default.
• W2049759397 cites W1990036406 @default.
• W2049759397 cites W1992111419 @default.
• W2049759397 cites W2001691760 @default.
• W2049759397 cites W2014670571 @default.
• W2049759397 cites W2020103206 @default.
• W2049759397 cites W2020711578 @default.
• W2049759397 cites W2040278638 @default.
• W2049759397 cites W2044515472 @default.
• W2049759397 cites W2051267797 @default.
• W2049759397 cites W2067050771 @default.
• W2049759397 cites W2072684190 @default.
• W2049759397 cites W2088704651 @default.
• W2049759397 cites W2132618877 @default.
• W2049759397 cites W2143308743 @default.
• W2049759397 cites W2166648967 @default.
• W2049759397 cites W2181619903 @default.
• W2049759397 cites W2183225184 @default.
• W2049759397 cites W2184454420 @default.
• W2049759397 cites W2185740607 @default.
• W2049759397 cites W2186106173 @default.
• W2049759397 cites W2331413810 @default.
• W2049759397 cites W2336083543 @default.
• W2049759397 cites W2363772089 @default.
• W2049759397 cites W2396377156 @default.
• W2049759397 cites W2417365582 @default.
• W2049759397 cites W2472416120 @default.
• W2049759397 cites W4290200763 @default.
• W2049759397 doi "https://doi.org/10.1172/jci116074" @default.
• W2049759397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/443258" @default.
• W2049759397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1430218" @default.
• W2049759397 hasPublicationYear "1992" @default.
• W2049759397 type Work @default.
• W2049759397 sameAs 2049759397 @default.
• W2049759397 citedByCount "42" @default.
• W2049759397 countsByYear W20497593972012 @default.
• W2049759397 countsByYear W20497593972016 @default.
• W2049759397 countsByYear W20497593972018 @default.
• W2049759397 countsByYear W20497593972022 @default.
• W2049759397 countsByYear W20497593972023 @default.
• W2049759397 crossrefType "journal-article" @default.
• W2049759397 hasAuthorship W2049759397A5044848732 @default.
• W2049759397 hasAuthorship W2049759397A5047572291 @default.
• W2049759397 hasAuthorship W2049759397A5056429133 @default.
• W2049759397 hasAuthorship W2049759397A5087893023 @default.
• W2049759397 hasBestOaLocation W20497593971 @default.
• W2049759397 hasConcept C11772777 @default.
• W2049759397 hasConcept C126322002 @default.
• W2049759397 hasConcept C134018914 @default.
• W2049759397 hasConcept C171089720 @default.
• W2049759397 hasConcept C185592680 @default.
• W2049759397 hasConcept C2778163477 @default.
• W2049759397 hasConcept C2778913445 @default.
• W2049759397 hasConcept C2779134260 @default.
• W2049759397 hasConcept C2780072125 @default.
• W2049759397 hasConcept C56623246 @default.
• W2049759397 hasConcept C57089818 @default.
• W2049759397 hasConcept C62231903 @default.
• W2049759397 hasConcept C62746215 @default.
• W2049759397 hasConcept C71924100 @default.
• W2049759397 hasConcept C8004288 @default.
• W2049759397 hasConcept C8243546 @default.
• W2049759397 hasConcept C86803240 @default.
• W2049759397 hasConcept C94879076 @default.
• W2049759397 hasConcept C96942376 @default.
• W2049759397 hasConceptScore W2049759397C11772777 @default.
• W2049759397 hasConceptScore W2049759397C126322002 @default.
• W2049759397 hasConceptScore W2049759397C134018914 @default.
• W2049759397 hasConceptScore W2049759397C171089720 @default.
• W2049759397 hasConceptScore W2049759397C185592680 @default.
• W2049759397 hasConceptScore W2049759397C2778163477 @default.
• W2049759397 hasConceptScore W2049759397C2778913445 @default.
• W2049759397 hasConceptScore W2049759397C2779134260 @default.
• W2049759397 hasConceptScore W2049759397C2780072125 @default.
• W2049759397 hasConceptScore W2049759397C56623246 @default.
• W2049759397 hasConceptScore W2049759397C57089818 @default.

• next