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- W2049759871 abstract "We have investigated the role of ion channels and intracellular Ca2+ in the regulation of hypoxia-mediated VPF/VEGF activation. Known channel activator and blockers like lemakalim, glibenclamide, tetraethylammonium, 4-aminopyridine and nifedipine do not inhibit VPF/VEGF induction due to hypoxia. Whereas, 5 mM caffeine pretreatment of the 293 cells exhibits a complete inhibition of hypoxia inducted VPF/VEGF expression. Moreover, the cells treated with BAPTA-AM prior to hypoxia also show a dramatic decrease in the VPF/VEGF message level, which suggests an important role of intracellular Ca2+ in this signaling pathway. Caffeine pretreatment also inhibits hypoxia-mediated c-Src kinase activity. These findings demonstrate the importance of intracellular Ca2+ in the event of hypoxia-induced VPF/VEGF expression." @default.
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- W2049759871 date "1996-12-01" @default.
- W2049759871 modified "2023-10-09" @default.
- W2049759871 title "Depletion of [Ca2+]i Inhibits Hypoxia-Induced Vascular Permeability Factor (Vascular Endothelial Growth Factor) Gene Expression" @default.
- W2049759871 doi "https://doi.org/10.1006/bbrc.1996.1873" @default.
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