Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049780451> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2049780451 endingPage "216" @default.
- W2049780451 startingPage "211" @default.
- W2049780451 abstract "CAD is the multifunctional protein of higher eukaryotes which catalyzes the first three steps of pyrimidine biosynthesis. Its enzymatic activities exist as independent domains in the order: N terminus-carbamylphosphate synthetase II(CPSase)-dihydroorotase(DHOase)-aspartate transcarbamylase(ATCase)-C terminus. To functionally define the minimum hamster cDNA region required to encode an active DHOase, expression constructs were generated. Many such constructs complement Escherichia coli mutants defective not only in DHOase but also in ATCase. Constructs deleted for most of the sequence encoding the ATCase domain continue to complement E. coli mutants defective in DHOase. All of these smaller constructs also lack the region encoding CPSase. Therefore, a 'genetic cassette', containing information for neither the CPSase nor the ATCase domain, can direct the synthesis of a polypeptide with DHOase activity. Interestingly, inclusion of a portion of the DHOase-ATCase interdomain bridge appears to be required for optimum activity." @default.
- W2049780451 created "2016-06-24" @default.
- W2049780451 creator A5022253996 @default.
- W2049780451 creator A5030724836 @default.
- W2049780451 creator A5075257836 @default.
- W2049780451 date "1991-03-01" @default.
- W2049780451 modified "2023-09-24" @default.
- W2049780451 title "Synthesis of the nonconserved dihydroorotase domain of the multifunctional hamster CAD protein in Escherichia coli" @default.
- W2049780451 cites W1492813001 @default.
- W2049780451 cites W1532688424 @default.
- W2049780451 cites W1545540883 @default.
- W2049780451 cites W1581174167 @default.
- W2049780451 cites W1584586118 @default.
- W2049780451 cites W1656600115 @default.
- W2049780451 cites W1658756073 @default.
- W2049780451 cites W1874448345 @default.
- W2049780451 cites W1966802815 @default.
- W2049780451 cites W1967163539 @default.
- W2049780451 cites W2001452629 @default.
- W2049780451 cites W2009069234 @default.
- W2049780451 cites W2017953423 @default.
- W2049780451 cites W2047465253 @default.
- W2049780451 cites W2050499271 @default.
- W2049780451 cites W2055880691 @default.
- W2049780451 cites W2063493022 @default.
- W2049780451 cites W2088535347 @default.
- W2049780451 cites W2095531248 @default.
- W2049780451 cites W2344984285 @default.
- W2049780451 cites W4243232554 @default.
- W2049780451 cites W4298046565 @default.
- W2049780451 doi "https://doi.org/10.1016/0378-1119(91)90129-y" @default.
- W2049780451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1673666" @default.
- W2049780451 hasPublicationYear "1991" @default.
- W2049780451 type Work @default.
- W2049780451 sameAs 2049780451 @default.
- W2049780451 citedByCount "14" @default.
- W2049780451 countsByYear W20497804512015 @default.
- W2049780451 crossrefType "journal-article" @default.
- W2049780451 hasAuthorship W2049780451A5022253996 @default.
- W2049780451 hasAuthorship W2049780451A5030724836 @default.
- W2049780451 hasAuthorship W2049780451A5075257836 @default.
- W2049780451 hasConcept C104317684 @default.
- W2049780451 hasConcept C143065580 @default.
- W2049780451 hasConcept C181199279 @default.
- W2049780451 hasConcept C187882448 @default.
- W2049780451 hasConcept C197248121 @default.
- W2049780451 hasConcept C200159599 @default.
- W2049780451 hasConcept C2776476023 @default.
- W2049780451 hasConcept C547475151 @default.
- W2049780451 hasConcept C55493867 @default.
- W2049780451 hasConcept C86803240 @default.
- W2049780451 hasConceptScore W2049780451C104317684 @default.
- W2049780451 hasConceptScore W2049780451C143065580 @default.
- W2049780451 hasConceptScore W2049780451C181199279 @default.
- W2049780451 hasConceptScore W2049780451C187882448 @default.
- W2049780451 hasConceptScore W2049780451C197248121 @default.
- W2049780451 hasConceptScore W2049780451C200159599 @default.
- W2049780451 hasConceptScore W2049780451C2776476023 @default.
- W2049780451 hasConceptScore W2049780451C547475151 @default.
- W2049780451 hasConceptScore W2049780451C55493867 @default.
- W2049780451 hasConceptScore W2049780451C86803240 @default.
- W2049780451 hasIssue "2" @default.
- W2049780451 hasLocation W20497804511 @default.
- W2049780451 hasLocation W20497804512 @default.
- W2049780451 hasOpenAccess W2049780451 @default.
- W2049780451 hasPrimaryLocation W20497804511 @default.
- W2049780451 hasRelatedWork W1967971144 @default.
- W2049780451 hasRelatedWork W1991271865 @default.
- W2049780451 hasRelatedWork W1997700015 @default.
- W2049780451 hasRelatedWork W1998202807 @default.
- W2049780451 hasRelatedWork W2003092871 @default.
- W2049780451 hasRelatedWork W2037745599 @default.
- W2049780451 hasRelatedWork W2055283392 @default.
- W2049780451 hasRelatedWork W2156002611 @default.
- W2049780451 hasRelatedWork W2170552338 @default.
- W2049780451 hasRelatedWork W2802160528 @default.
- W2049780451 hasVolume "99" @default.
- W2049780451 isParatext "false" @default.
- W2049780451 isRetracted "false" @default.
- W2049780451 magId "2049780451" @default.
- W2049780451 workType "article" @default.