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- W2049793604 abstract "SUMMARY The highly specialized cephalopod cardiovascular system has long been considered a valuable model for understanding the evolution of circulatory systems. Despite the number of studies devoted to this topic, the developmental regulatory mechanisms remain largely unexplored. Here, we focus on the vascular endothelial growth factor receptor (VEGFR). This factor is known to mediate levels of endothelial growth factor that is involved in hematopoiesis and vasculogenesis including multichambered heart development in vertebrates. We found a squid VEGFR ortholog that is expressed in the developing blood vessels, notably in the sheet‐like endothelial cells of the systemic and branchial hearts. The highly restricted localization of VEGFR in the vascular endothelial cells and its shared expression pattern in the developing hearts of cephalopods and vertebrates suggest a shared molecular signature of closed circulatory systems that has been independently elaborated during evolution." @default.
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- W2049793604 date "2010-01-01" @default.
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- W2049793604 title "Squid vascular endothelial growth factor receptor: a shared molecular signature in the convergent evolution of closed circulatory systems" @default.
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- W2049793604 doi "https://doi.org/10.1111/j.1525-142x.2009.00388.x" @default.
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