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• W2049793957 abstract "Myofibril disintegration in rat skeletal muscle fibers denervated at early stages of development is accompanied by increase in number and size of lysosomes with concomitant hypertrophy of the Golgi apparatus. Dense bodies, cuplike bodies, multivesicular bodies, and digestive vacuoles containing amorphous material are especially conspicuous in the denervated muscle cells. Autophagic vacuoles containing recognizable cytoplasmic components are also seen, but intact myofilaments are never found segregated within autophagic vacuoles. Acid phosphatase and aryl sulfatase activities are present, though not consistently, in the different lysosomal structures. Diffuse reaction product is never observed in preparations incubated for acid hydrolase activity. The findings suggest that myofibril disintegration in the course of denervation atrophy of skeletal muscles does not result from lysosomal activation, but is presumably initiated by extralysosomal mechanisms. On the other hand, it appears possible that the accumulation of degradation products arising from the breakdown of the myofibrils in the ground cytoplasm may stimulate lysosome formation and induce autophagic processes." @default.
• W2049793957 created "2016-06-24" @default.
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• W2049793957 date "1972-04-01" @default.
• W2049793957 modified "2023-09-24" @default.
• W2049793957 title "Studies on the effect of denervation in developing muscle. II. The lysosomal system" @default.
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• W2049793957 doi "https://doi.org/10.1016/s0022-5320(72)80002-9" @default.
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