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• W2049804712 abstract "Fingerprints have been prepared of RNase T1- and RNase A-resistant oligonucleotides of poliovirus type 1 (Mahoney) and its attenuated derivative, the Sabin vaccine strain LSc 2ab. Changes in the position of seven oligonucleotides have been observed and correlated by sequence analysis with transversions and transitions. Based on mapping procedures (A. Nomoto, A. Jacobson, Y. F. Lee, J. J. Dunn, and Eckard Wimmer, 1979, J. Mol. Biol.128, 179–196) and sequence studies (N. Kitamura and E. Wimmer, 1980, Proc. Nat. Acad. Sci. USA77, 3196–3200) the mutations have been localized within the viral genome. Assuming random distribution of the mutations our results imply that approximately 35 base changes may have occurred during attenuation of poliovirus type 1 (Mahoney). A catalogue of sequences of 55 RNase T1- and 16 RNase A-resistant oligonucleotides has been established." @default.
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• W2049804712 date "1981-07-01" @default.
• W2049804712 modified "2023-09-25" @default.
• W2049804712 title "Identification of point mutations in the genome of the poliovirus sabin vaccine LSc 2ab, and catalogue of RNase T1- and RNase A-resistant oligonucleotides of poliovirus type 1 (Mahoney) RNA" @default.
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• W2049804712 doi "https://doi.org/10.1016/0042-6822(81)90627-9" @default.
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