FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049814940> ?p ?o ?g. }

• W2049814940 endingPage "e74943" @default.
• W2049814940 startingPage "e74943" @default.
• W2049814940 abstract "Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This study aimed to determine the inflammatory role of N/OFQ and its receptor NOP (ORL1) within the microcirculation, along with anti-inflammatory effects of the NOP antagonist UFP-101 (University of Ferrara Peptide-101) in an animal model of sepsis (endotoxemia). Male Wistar rats (220 to 300 g) were administered lipopolysaccharide (LPS) for 24 h (-24 h, 1 mg kg(-1); -2 h, 1 mg kg(-1) i.v., tail vein). They were then either anesthetised for observation of the mesenteric microcirculation using fluorescent in vivo microscopy, or isolated arterioles (~200 µm) were studied in vitro with pressure myography. 200 nM kg(-1) fluorescently labelled N/OFQ (FITC-N/OFQ, i.a., mesenteric artery) bound to specific sites on the microvascular endothelium in vivo, indicating sparse distribution of NOP receptors. In vitro, arterioles (~200 µm) dilated to intraluminal N/OFQ (10(-5)M) (32.6 + 8.4%) and this response was exaggerated with LPS (62.0 +7.9%, p=0.031). In vivo, LPS induced macromolecular leak of FITC-BSA (0.02 g kg(-1) i.v.) (LPS: 95.3 (86.7 to 97.9)%, p=0.043) from post-capillary venules (<40 µm) and increased leukocyte rolling as endotoxemia progressed (p=0.027), both being reduced by 150 nmol kg(-1) UFP-101 (i.v., jugular vein). Firstly, the rat mesenteric microcirculation expresses NOP receptors and secondly, NOP function (ability to induce dilation) is enhanced with LPS. UFP-101 also reduced microvascular inflammation to endotoxemia in vivo. Hence inhibition of the microvascular N/OFQ-NOP pathway may have therapeutic potential during sepsis and warrants further investigation." @default.
• W2049814940 created "2016-06-24" @default.
• W2049814940 creator A5016753393 @default.
• W2049814940 creator A5023630611 @default.
• W2049814940 creator A5028341235 @default.
• W2049814940 creator A5044328039 @default.
• W2049814940 creator A5056553308 @default.
• W2049814940 creator A5061719307 @default.
• W2049814940 creator A5067174803 @default.
• W2049814940 creator A5087092305 @default.
• W2049814940 date "2013-09-23" @default.
• W2049814940 modified "2023-10-18" @default.
• W2049814940 title "The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo" @default.
• W2049814940 cites W1963782044 @default.
• W2049814940 cites W1972465709 @default.
• W2049814940 cites W1981050316 @default.
• W2049814940 cites W1981330828 @default.
• W2049814940 cites W1991711350 @default.
• W2049814940 cites W1997675350 @default.
• W2049814940 cites W2000027332 @default.
• W2049814940 cites W2006445444 @default.
• W2049814940 cites W2008927766 @default.
• W2049814940 cites W2012382011 @default.
• W2049814940 cites W2014598698 @default.
• W2049814940 cites W2015143316 @default.
• W2049814940 cites W2030697512 @default.
• W2049814940 cites W2032005626 @default.
• W2049814940 cites W2046320010 @default.
• W2049814940 cites W2048130564 @default.
• W2049814940 cites W2049927822 @default.
• W2049814940 cites W2052953255 @default.
• W2049814940 cites W2053284320 @default.
• W2049814940 cites W2057613501 @default.
• W2049814940 cites W2058988366 @default.
• W2049814940 cites W2063031513 @default.
• W2049814940 cites W2067752549 @default.
• W2049814940 cites W2074631079 @default.
• W2049814940 cites W2095209996 @default.
• W2049814940 cites W2098212247 @default.
• W2049814940 cites W2126531130 @default.
• W2049814940 cites W2128576523 @default.
• W2049814940 cites W2128592505 @default.
• W2049814940 cites W2136276105 @default.
• W2049814940 cites W2144916874 @default.
• W2049814940 cites W2147080208 @default.
• W2049814940 cites W2151891132 @default.
• W2049814940 cites W2170071096 @default.
• W2049814940 doi "https://doi.org/10.1371/journal.pone.0074943" @default.
• W2049814940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3781147" @default.
• W2049814940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24086402" @default.
• W2049814940 hasPublicationYear "2013" @default.
• W2049814940 type Work @default.
• W2049814940 sameAs 2049814940 @default.
• W2049814940 citedByCount "11" @default.
• W2049814940 countsByYear W20498149402014 @default.
• W2049814940 countsByYear W20498149402015 @default.
• W2049814940 countsByYear W20498149402016 @default.
• W2049814940 countsByYear W20498149402022 @default.
• W2049814940 crossrefType "journal-article" @default.
• W2049814940 hasAuthorship W2049814940A5016753393 @default.
• W2049814940 hasAuthorship W2049814940A5023630611 @default.
• W2049814940 hasAuthorship W2049814940A5028341235 @default.
• W2049814940 hasAuthorship W2049814940A5044328039 @default.
• W2049814940 hasAuthorship W2049814940A5056553308 @default.
• W2049814940 hasAuthorship W2049814940A5061719307 @default.
• W2049814940 hasAuthorship W2049814940A5067174803 @default.
• W2049814940 hasAuthorship W2049814940A5087092305 @default.
• W2049814940 hasBestOaLocation W20498149401 @default.
• W2049814940 hasConcept C125439840 @default.
• W2049814940 hasConcept C126322002 @default.
• W2049814940 hasConcept C12722491 @default.
• W2049814940 hasConcept C134018914 @default.
• W2049814940 hasConcept C150903083 @default.
• W2049814940 hasConcept C159023312 @default.
• W2049814940 hasConcept C170493617 @default.
• W2049814940 hasConcept C185592680 @default.
• W2049814940 hasConcept C207001950 @default.
• W2049814940 hasConcept C2776885963 @default.
• W2049814940 hasConcept C2776914184 @default.
• W2049814940 hasConcept C2777649898 @default.
• W2049814940 hasConcept C2778672379 @default.
• W2049814940 hasConcept C2778754761 @default.
• W2049814940 hasConcept C2779886867 @default.
• W2049814940 hasConcept C2781063702 @default.
• W2049814940 hasConcept C2859252 @default.
• W2049814940 hasConcept C71924100 @default.
• W2049814940 hasConcept C86803240 @default.
• W2049814940 hasConcept C88016717 @default.
• W2049814940 hasConcept C98274493 @default.
• W2049814940 hasConceptScore W2049814940C125439840 @default.
• W2049814940 hasConceptScore W2049814940C126322002 @default.
• W2049814940 hasConceptScore W2049814940C12722491 @default.
• W2049814940 hasConceptScore W2049814940C134018914 @default.
• W2049814940 hasConceptScore W2049814940C150903083 @default.
• W2049814940 hasConceptScore W2049814940C159023312 @default.
• W2049814940 hasConceptScore W2049814940C170493617 @default.
• W2049814940 hasConceptScore W2049814940C185592680 @default.
• W2049814940 hasConceptScore W2049814940C207001950 @default.

• next