FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049828621> ?p ?o ?g. }

• W2049828621 endingPage "3878" @default.
• W2049828621 startingPage "3865" @default.
• W2049828621 abstract "During corticogenesis, pituitary adenylate cyclase-activating polypeptide (PACAP; ADCYAP1) may contribute to proliferation control by activating PAC1 receptors of neural precursors in the embryonic ventricular zone. PAC1 receptors, specifically the hop and short isoforms, couple differentially to and activate distinct pathways that produce pro- or anti-mitogenic actions. Previously, we found that PACAP was an anti-mitogenic signal from embryonic day 13.5 (E13.5) onward both in culture and in vivo and activated cAMP signaling through the short isoform. However, we now find that mice deficient in PACAP exhibited a decrease in the BrdU labeling index (LI) in E9.5 cortex, suggesting that PACAP normally promotes proliferation at this stage. To further define mechanisms, we established a novel culture model in which the viability of very early cortical precursors (E9.5 mouse and E10.5 rat) could be maintained. At this stage, we found that PACAP evoked intracellular calcium fluxes and increased phospho-PKC levels, as well as stimulated G1 cyclin mRNAs and proteins, S-phase entry, and proliferation without affecting cell survival. Significantly, expression of hop receptor isoform was 24-fold greater than the short isoform at E10.5, a ratio that was reversed at E14.5 when short expression was 15-fold greater and PACAP inhibited mitogenesis. Enhanced hop isoform expression, elicited by in vitro treatment of E10.5 precursors with retinoic acid, correlated with sustained pro-mitogenic action of PACAP beyond the developmental switch. Conversely, depletion of hop receptor using short-hairpin RNA abolished PACAP mitogenic stimulation at E10.5. These observations suggest that PACAP elicits temporally specific effects on cortical proliferation via developmentally regulated expression of specific receptor isoforms." @default.
• W2049828621 created "2016-06-24" @default.
• W2049828621 creator A5005855723 @default.
• W2049828621 creator A5015264004 @default.
• W2049828621 creator A5025549159 @default.
• W2049828621 creator A5048411184 @default.
• W2049828621 creator A5064655521 @default.
• W2049828621 creator A5077746312 @default.
• W2049828621 date "2013-02-27" @default.
• W2049828621 modified "2023-09-23" @default.
• W2049828621 title "Pro- and Anti-Mitogenic Actions of Pituitary Adenylate Cyclase-Activating Polypeptide in Developing Cerebral Cortex: Potential Mediation by Developmental Switch of PAC1 Receptor mRNA Isoforms" @default.
• W2049828621 cites W1485297825 @default.
• W2049828621 cites W1500158856 @default.
• W2049828621 cites W1543151032 @default.
• W2049828621 cites W1546116904 @default.
• W2049828621 cites W1579609657 @default.
• W2049828621 cites W1599277155 @default.
• W2049828621 cites W1608092431 @default.
• W2049828621 cites W1785202197 @default.
• W2049828621 cites W1965681567 @default.
• W2049828621 cites W1966936548 @default.
• W2049828621 cites W1970774026 @default.
• W2049828621 cites W1979067492 @default.
• W2049828621 cites W1987137750 @default.
• W2049828621 cites W1988653619 @default.
• W2049828621 cites W1991399785 @default.
• W2049828621 cites W1992375433 @default.
• W2049828621 cites W1995319712 @default.
• W2049828621 cites W1995790354 @default.
• W2049828621 cites W1997975361 @default.
• W2049828621 cites W2001692359 @default.
• W2049828621 cites W2003548070 @default.
• W2049828621 cites W2006655885 @default.
• W2049828621 cites W2015714994 @default.
• W2049828621 cites W2016853574 @default.
• W2049828621 cites W2019397670 @default.
• W2049828621 cites W2020447498 @default.
• W2049828621 cites W2024064411 @default.
• W2049828621 cites W2025199740 @default.
• W2049828621 cites W2028856874 @default.
• W2049828621 cites W2032466814 @default.
• W2049828621 cites W2033045687 @default.
• W2049828621 cites W2033726122 @default.
• W2049828621 cites W2038627582 @default.
• W2049828621 cites W2041538361 @default.
• W2049828621 cites W2046859370 @default.
• W2049828621 cites W2049198952 @default.
• W2049828621 cites W2051033394 @default.
• W2049828621 cites W2056137734 @default.
• W2049828621 cites W2058788414 @default.
• W2049828621 cites W2067573274 @default.
• W2049828621 cites W2068480672 @default.
• W2049828621 cites W2071435286 @default.
• W2049828621 cites W2072469132 @default.
• W2049828621 cites W2076542702 @default.
• W2049828621 cites W2083131697 @default.
• W2049828621 cites W2083515911 @default.
• W2049828621 cites W2083864798 @default.
• W2049828621 cites W2084314209 @default.
• W2049828621 cites W2086358418 @default.
• W2049828621 cites W2089084448 @default.
• W2049828621 cites W2090849704 @default.
• W2049828621 cites W2094119136 @default.
• W2049828621 cites W2100007797 @default.
• W2049828621 cites W2102921818 @default.
• W2049828621 cites W2127220436 @default.
• W2049828621 cites W2127585547 @default.
• W2049828621 cites W2128441790 @default.
• W2049828621 cites W2131306660 @default.
• W2049828621 cites W2132781656 @default.
• W2049828621 cites W2135547475 @default.
• W2049828621 cites W2149380656 @default.
• W2049828621 cites W2153887599 @default.
• W2049828621 cites W2156574899 @default.
• W2049828621 cites W2156979070 @default.
• W2049828621 cites W2167275747 @default.
• W2049828621 cites W2169501865 @default.
• W2049828621 doi "https://doi.org/10.1523/jneurosci.1062-12.2013" @default.
• W2049828621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3652328" @default.
• W2049828621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23447598" @default.
• W2049828621 hasPublicationYear "2013" @default.
• W2049828621 type Work @default.
• W2049828621 sameAs 2049828621 @default.
• W2049828621 citedByCount "36" @default.
• W2049828621 countsByYear W20498286212013 @default.
• W2049828621 countsByYear W20498286212014 @default.
• W2049828621 countsByYear W20498286212015 @default.
• W2049828621 countsByYear W20498286212016 @default.
• W2049828621 countsByYear W20498286212017 @default.
• W2049828621 countsByYear W20498286212018 @default.
• W2049828621 countsByYear W20498286212019 @default.
• W2049828621 countsByYear W20498286212020 @default.
• W2049828621 countsByYear W20498286212021 @default.
• W2049828621 countsByYear W20498286212022 @default.
• W2049828621 countsByYear W20498286212023 @default.
• W2049828621 crossrefType "journal-article" @default.
• W2049828621 hasAuthorship W2049828621A5005855723 @default.
• W2049828621 hasAuthorship W2049828621A5015264004 @default.

• next