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- W2049830791 abstract "Abstract Strategies for the use of germanium‐based linkers for the phase‐tagged synthesis of isotopically labelled intermediates are described. Protocols of potential use in the devolatilization of volatile intermediates prepared from [ 14 C]‐CO 2 and [ 14 C]‐PhBr to aid ADME studies on drug substances and their metabolites are discussed in relation to SR47035 (an advanced intermediate en‐route to the 5‐HT 2 receptor antagonist SR46349B) and 4‐amino‐4‐phenylpiperidine (a key intermediate in the synthesis of NK 3 receptor antagonist SR142801, osanetant). Additionally, protocols with potential for the preparation of [ 123 I] and [ 18 F]‐labelled SPECT/PET imaging/diagnostic agents are discussed in relation to an [ 123 I]‐labelled analogue of SR141716 (rimonabant, a CB 1 receptor antagonist) and 6‐[ 18 F]‐( S )‐DOPA (for diagnosis of Parkinson's disease). Copyright © 2007 John Wiley & Sons, Ltd." @default.
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- W2049830791 date "2007-04-01" @default.
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- W2049830791 title "Opportunities for isotopic labelling via phase‐tagged synthesis with organogermanium linkers" @default.
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- W2049830791 doi "https://doi.org/10.1002/jlcr.1302" @default.
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