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• W2049831489 endingPage "1774" @default.
• W2049831489 startingPage "1767" @default.
• W2049831489 abstract "Antioxidant and antimelanogenesis activities of protocatechuic acid (1) from Origanum vulgare (oregano) were investigated. The antioxidative capacity of 1 was confirmed from its free-radical-scavenging activities, inhibition of lipid peroxidation, and suppression of reactive oxygen species in H2O2-induced BNLCL2 cells. The inhibition by 1 of tyrosinase and DOPA oxidase activity and melanin production was possibly related to the down-regulation of melanocortin-1 receptor, microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related proteins-2, and tyrosinase-related proteins-1 expression in α-melanocyte-stimulating hormone-induced B16 cells. After a gel containing 1 was applied to mice, the values of L* slightly increased, and a* and erythema-melanin levels of skin were reduced by comparing the values of untreated control groups, indicating 1 can reduce melanin production. These results suggest that 1 may act as an effective quencher of oxidative attackers with antimelanogenesis properties." @default.
• W2049831489 created "2016-06-24" @default.
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• W2049831489 date "2010-10-25" @default.
• W2049831489 modified "2023-09-25" @default.
• W2049831489 title "Inhibition of Melanogenesis and Oxidation by Protocatechuic Acid from <i>Origanum vulgare</i> (Oregano)" @default.
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• W2049831489 doi "https://doi.org/10.1021/np100281g" @default.
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