FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049832013> ?p ?o ?g. }

• W2049832013 abstract "Although there are a lot of researches focusing on cancer prognosis or prediction of cancer metastases, it is still a big challenge to predict the risks of cancer metastasizing to a specific organ such as bone. In fact, little work has been published for such a purpose nowadays. In this work, we propose a Dysregulated Pathway Based prediction Model (DPBM) built on a merged data set with 855 samples. First, we use bootstrapping strategy to select bone metastasis related genes. Based on the selected genes, we then detect out the dysregulated pathways involved in the process of bone metastasis via enrichment analysis. And then we use the discriminative genes in each dysregulated pathway, called as dysregulated genes, to construct a sub-model to forecast the risk of bone metastasis. Finally we combine all sub-models as an ensemble model (DPBM) to predict the risk of bone metastasis. We have validated DPBM on the training, test and independent sets separately, and the results show that DPBM can significantly distinguish the bone metastases risks of patients (with p-values of 3.82E-10, 0.00007 and 0.0003 on three sets respectively). Moreover, the dysregulated genes are generally with higher topological coefficients (degree and betweenness centrality) in the PPI network, which means that they may play critical roles in the biological functions. Further functional analysis of these genes demonstrates that the immune system seems to play an important role in bone-specific metastasis of breast cancer. Each of the dysregulated pathways that are enriched with bone metastasis related genes may uncover one critical aspect of influencing the bone metastasis of breast cancer, thus the ensemble strategy can help to describe the comprehensive view of bone metastasis mechanism. Therefore, the constructed DPBM is robust and able to significantly distinguish the bone metastases risks of patients in both test set and independent set. Moreover, the dysregulated genes in the dysregulated pathways tend to play critical roles in the biological process of bone metastasis of breast cancer." @default.
• W2049832013 created "2016-06-24" @default.
• W2049832013 creator A5022647677 @default.
• W2049832013 creator A5080125836 @default.
• W2049832013 date "2014-08-27" @default.
• W2049832013 modified "2023-09-26" @default.
• W2049832013 title "A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways" @default.
• W2049832013 cites W1512072225 @default.
• W2049832013 cites W1964764106 @default.
• W2049832013 cites W1966230941 @default.
• W2049832013 cites W1966535852 @default.
• W2049832013 cites W1968564472 @default.
• W2049832013 cites W1969473394 @default.
• W2049832013 cites W1978596758 @default.
• W2049832013 cites W1978675364 @default.
• W2049832013 cites W1984086503 @default.
• W2049832013 cites W1986471913 @default.
• W2049832013 cites W1992045522 @default.
• W2049832013 cites W1992762981 @default.
• W2049832013 cites W2007917153 @default.
• W2049832013 cites W2011340259 @default.
• W2049832013 cites W2012009763 @default.
• W2049832013 cites W2022397091 @default.
• W2049832013 cites W2030689322 @default.
• W2049832013 cites W2039854218 @default.
• W2049832013 cites W2045479282 @default.
• W2049832013 cites W2050143878 @default.
• W2049832013 cites W2051255001 @default.
• W2049832013 cites W2057151160 @default.
• W2049832013 cites W2067472741 @default.
• W2049832013 cites W2082634661 @default.
• W2049832013 cites W2082833890 @default.
• W2049832013 cites W2090247362 @default.
• W2049832013 cites W2090802890 @default.
• W2049832013 cites W2097289205 @default.
• W2049832013 cites W2100193180 @default.
• W2049832013 cites W2102969047 @default.
• W2049832013 cites W2104447833 @default.
• W2049832013 cites W2107471637 @default.
• W2049832013 cites W2109276980 @default.
• W2049832013 cites W2110151517 @default.
• W2049832013 cites W2114066886 @default.
• W2049832013 cites W2118413367 @default.
• W2049832013 cites W2124618015 @default.
• W2049832013 cites W2127906261 @default.
• W2049832013 cites W2130410032 @default.
• W2049832013 cites W2138550913 @default.
• W2049832013 cites W2144206769 @default.
• W2049832013 cites W2144656637 @default.
• W2049832013 cites W2145013849 @default.
• W2049832013 cites W2145259857 @default.
• W2049832013 cites W2154947819 @default.
• W2049832013 cites W2156323704 @default.
• W2049832013 cites W2158217645 @default.
• W2049832013 cites W2160450758 @default.
• W2049832013 cites W2168264491 @default.
• W2049832013 cites W4245024447 @default.
• W2049832013 doi "https://doi.org/10.1186/1471-2407-14-618" @default.
• W2049832013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4161863" @default.
• W2049832013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25163697" @default.
• W2049832013 hasPublicationYear "2014" @default.
• W2049832013 type Work @default.
• W2049832013 sameAs 2049832013 @default.
• W2049832013 citedByCount "13" @default.
• W2049832013 countsByYear W20498320132015 @default.
• W2049832013 countsByYear W20498320132016 @default.
• W2049832013 countsByYear W20498320132018 @default.
• W2049832013 countsByYear W20498320132019 @default.
• W2049832013 countsByYear W20498320132021 @default.
• W2049832013 countsByYear W20498320132023 @default.
• W2049832013 crossrefType "journal-article" @default.
• W2049832013 hasAuthorship W2049832013A5022647677 @default.
• W2049832013 hasAuthorship W2049832013A5080125836 @default.
• W2049832013 hasBestOaLocation W20498320131 @default.
• W2049832013 hasConcept C121608353 @default.
• W2049832013 hasConcept C126322002 @default.
• W2049832013 hasConcept C143998085 @default.
• W2049832013 hasConcept C2777783956 @default.
• W2049832013 hasConcept C2779013556 @default.
• W2049832013 hasConcept C2780140570 @default.
• W2049832013 hasConcept C530470458 @default.
• W2049832013 hasConcept C60644358 @default.
• W2049832013 hasConcept C70721500 @default.
• W2049832013 hasConcept C71924100 @default.
• W2049832013 hasConcept C86803240 @default.
• W2049832013 hasConceptScore W2049832013C121608353 @default.
• W2049832013 hasConceptScore W2049832013C126322002 @default.
• W2049832013 hasConceptScore W2049832013C143998085 @default.
• W2049832013 hasConceptScore W2049832013C2777783956 @default.
• W2049832013 hasConceptScore W2049832013C2779013556 @default.
• W2049832013 hasConceptScore W2049832013C2780140570 @default.
• W2049832013 hasConceptScore W2049832013C530470458 @default.
• W2049832013 hasConceptScore W2049832013C60644358 @default.
• W2049832013 hasConceptScore W2049832013C70721500 @default.
• W2049832013 hasConceptScore W2049832013C71924100 @default.
• W2049832013 hasConceptScore W2049832013C86803240 @default.
• W2049832013 hasIssue "1" @default.
• W2049832013 hasLocation W20498320131 @default.
• W2049832013 hasLocation W20498320132 @default.
• W2049832013 hasLocation W20498320133 @default.

• next