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- W2049841883 abstract "The possible role of cyclic AMP (cAMP) in the regulation of the vasopressin (VP) gene was tested in two cellular expression systems: one cell line with endogenous VP expression and the other which was transiently with a VP promoter-luciferase fusion gene. 8,Bromo-cAMP stimulated the VP mRNA content about 4-fold in the human VP-expressing small cell lung carcinoma cell line GLC-8. The luciferase activity in P19 embryonal carcinoma cells which were transiently transfected with -174 to +44 of the 5'-flanking region of the human VP gene linked to the firefly luciferase gene, was stimulated about 2-fold by the cAMP analogue. The results indicate that cAMP plays a role in the upregulation of the VP gene and hence point to several putative nucleotide motives in the promoter functionally conferring this response." @default.
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- W2049841883 date "1990-10-15" @default.
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- W2049841883 title "Vasopressin gene expression is stimulated by cyclic AMP in homologous and heterologous expression systems" @default.
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- W2049841883 doi "https://doi.org/10.1016/0014-5793(90)80455-r" @default.
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