FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049841970> ?p ?o ?g. }

• W2049841970 endingPage "201" @default.
• W2049841970 startingPage "193" @default.
• W2049841970 abstract "We have tested the hypothesis that leukotriene D4 (LTD4) receptor activation is involved in the development of antigen-induced bronchoconstriction. In two studies, patients with asthma received infusions of placebo or MK-571, a potent and specific LTD4 receptor antagonist (450 mg or 37.5 mg total dose, respectively). Antigen was inhaled during test-drug administration, and FEV1 was measured for 10 hours after challenge. Urine samples were collected for measurement of LTE4; plasma samples were drawn repeatedly for assay of MK-571. MK-571 infusions inhibited both immediate (0 to 3 hours) and late (3 to 10 hours) asthmatic responses. For the high MK-571 dose, the extent of inhibition, as assessed by the area under the curve of FEV1 versus time was 88% (p = 0.01) and 63% (p = 0.01), for immediate and late responses, respectively. The low MK-571 dose also inhibited both responses but to a minor extent. Mean urinary LTE4 excretion was elevated after antigen challenge and was unaffected by administration of the LTD4 receptor antagonist. The present study demonstrates that MK-571 inhibits antigen-induced asthma in a dose-related fashion; it had not effect on antigen-induced increases in urinary LTE4 excretions. The results suggest that LTD4 receptor activation plays an important role in antigen-induced asthma." @default.
• W2049841970 created "2016-06-24" @default.
• W2049841970 creator A5012080878 @default.
• W2049841970 creator A5014135786 @default.
• W2049841970 creator A5061107549 @default.
• W2049841970 creator A5062003722 @default.
• W2049841970 creator A5079743097 @default.
• W2049841970 creator A5089959588 @default.
• W2049841970 date "1992-08-01" @default.
• W2049841970 modified "2023-10-18" @default.
• W2049841970 title "Leukotriene D receptor blockade inhibits the immediate and late bronchoconstrictor responses to inhaled antigen in patients with asthma" @default.
• W2049841970 cites W1843291397 @default.
• W2049841970 cites W1887738083 @default.
• W2049841970 cites W1915136464 @default.
• W2049841970 cites W1972439638 @default.
• W2049841970 cites W1989314580 @default.
• W2049841970 cites W1998095641 @default.
• W2049841970 cites W2002199871 @default.
• W2049841970 cites W2002351007 @default.
• W2049841970 cites W2013194198 @default.
• W2049841970 cites W2022724314 @default.
• W2049841970 cites W2024176341 @default.
• W2049841970 cites W2030736050 @default.
• W2049841970 cites W2046262741 @default.
• W2049841970 cites W2049796670 @default.
• W2049841970 cites W2055320199 @default.
• W2049841970 cites W2066950125 @default.
• W2049841970 cites W2072259664 @default.
• W2049841970 cites W2076546406 @default.
• W2049841970 cites W2092887324 @default.
• W2049841970 cites W2095265570 @default.
• W2049841970 cites W2137629573 @default.
• W2049841970 cites W2160457267 @default.
• W2049841970 cites W2168666754 @default.
• W2049841970 cites W2201511800 @default.
• W2049841970 cites W2276213025 @default.
• W2049841970 cites W2292097566 @default.
• W2049841970 cites W2419284391 @default.
• W2049841970 doi "https://doi.org/10.1016/0091-6749(92)90071-9" @default.
• W2049841970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1323587" @default.
• W2049841970 hasPublicationYear "1992" @default.
• W2049841970 type Work @default.
• W2049841970 sameAs 2049841970 @default.
• W2049841970 citedByCount "123" @default.
• W2049841970 countsByYear W20498419702012 @default.
• W2049841970 crossrefType "journal-article" @default.
• W2049841970 hasAuthorship W2049841970A5012080878 @default.
• W2049841970 hasAuthorship W2049841970A5014135786 @default.
• W2049841970 hasAuthorship W2049841970A5061107549 @default.
• W2049841970 hasAuthorship W2049841970A5062003722 @default.
• W2049841970 hasAuthorship W2049841970A5079743097 @default.
• W2049841970 hasAuthorship W2049841970A5089959588 @default.
• W2049841970 hasConcept C126322002 @default.
• W2049841970 hasConcept C134018914 @default.
• W2049841970 hasConcept C142724271 @default.
• W2049841970 hasConcept C147483822 @default.
• W2049841970 hasConcept C170493617 @default.
• W2049841970 hasConcept C203014093 @default.
• W2049841970 hasConcept C204787440 @default.
• W2049841970 hasConcept C27081682 @default.
• W2049841970 hasConcept C2776042228 @default.
• W2049841970 hasConcept C2776452501 @default.
• W2049841970 hasConcept C2776885963 @default.
• W2049841970 hasConcept C2777242621 @default.
• W2049841970 hasConcept C2778053663 @default.
• W2049841970 hasConcept C2778122271 @default.
• W2049841970 hasConcept C2780212800 @default.
• W2049841970 hasConcept C2780769369 @default.
• W2049841970 hasConcept C71924100 @default.
• W2049841970 hasConcept C98274493 @default.
• W2049841970 hasConceptScore W2049841970C126322002 @default.
• W2049841970 hasConceptScore W2049841970C134018914 @default.
• W2049841970 hasConceptScore W2049841970C142724271 @default.
• W2049841970 hasConceptScore W2049841970C147483822 @default.
• W2049841970 hasConceptScore W2049841970C170493617 @default.
• W2049841970 hasConceptScore W2049841970C203014093 @default.
• W2049841970 hasConceptScore W2049841970C204787440 @default.
• W2049841970 hasConceptScore W2049841970C27081682 @default.
• W2049841970 hasConceptScore W2049841970C2776042228 @default.
• W2049841970 hasConceptScore W2049841970C2776452501 @default.
• W2049841970 hasConceptScore W2049841970C2776885963 @default.
• W2049841970 hasConceptScore W2049841970C2777242621 @default.
• W2049841970 hasConceptScore W2049841970C2778053663 @default.
• W2049841970 hasConceptScore W2049841970C2778122271 @default.
• W2049841970 hasConceptScore W2049841970C2780212800 @default.
• W2049841970 hasConceptScore W2049841970C2780769369 @default.
• W2049841970 hasConceptScore W2049841970C71924100 @default.
• W2049841970 hasConceptScore W2049841970C98274493 @default.
• W2049841970 hasIssue "2" @default.
• W2049841970 hasLocation W20498419701 @default.
• W2049841970 hasLocation W20498419702 @default.
• W2049841970 hasOpenAccess W2049841970 @default.
• W2049841970 hasPrimaryLocation W20498419701 @default.
• W2049841970 hasRelatedWork W1971099282 @default.
• W2049841970 hasRelatedWork W2025056137 @default.
• W2049841970 hasRelatedWork W2037971296 @default.
• W2049841970 hasRelatedWork W2054604027 @default.
• W2049841970 hasRelatedWork W2068047407 @default.

• next