FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049871389> ?p ?o ?g. }

• W2049871389 abstract "Human tumor-associated antigens (TAAs) are weak immunogens. One strategy for increasing the immunogenicity of TAAs is to generate altered peptide ligands. In the studies reported here, microarray technology has been used to compare gene expression profiles of a human T cell line that was derived from the peripheral blood of a cancer patient vaccinated with a carcinoembryonic antigen (CEA)-based vaccine. We compared the gene expression profiles of this CEA-specific CD8 T cell line when (a) stimulated with the native peptide used to derive this line vs. no peptide, and (b) stimulated with its TCR enhancer agonist epitope vs. no peptide. The results demonstrate that the effect on the T cell line, when stimulated with the agonist peptide, is not an enhanced quantitative expression of the same genes or gene sets induced by the native peptide, but is rather a nearly reciprocal upregulation of different gene sets. The gene for the chemokine lymphotactin, which was overexpressed only in T cells stimulated with the agonist peptide, stood out above all others. This finding was extended using other T cell lines, and another set of agonist and native peptides from another TAA. ELISPOT and ELISA assays for lymphotactin confirmed and extended these findings. These studies suggest a potential role for lymphotactin in the T-cell activation processes and subsequent anti-tumor events." @default.
• W2049871389 created "2016-06-24" @default.
• W2049871389 creator A5000012917 @default.
• W2049871389 creator A5018956979 @default.
• W2049871389 creator A5059931764 @default.
• W2049871389 creator A5068002072 @default.
• W2049871389 creator A5073536820 @default.
• W2049871389 creator A5081826448 @default.
• W2049871389 date "2003-11-01" @default.
• W2049871389 modified "2023-09-26" @default.
• W2049871389 title "Enhanced expression of lymphotactin by CD8+ T cells is selectively induced by enhancer agonist peptides of tumor-associated antigens" @default.
• W2049871389 cites W1493034773 @default.
• W2049871389 cites W1593820219 @default.
• W2049871389 cites W1599999513 @default.
• W2049871389 cites W1623078040 @default.
• W2049871389 cites W1928212615 @default.
• W2049871389 cites W1960833366 @default.
• W2049871389 cites W1983806918 @default.
• W2049871389 cites W1990507442 @default.
• W2049871389 cites W2004308954 @default.
• W2049871389 cites W2012148175 @default.
• W2049871389 cites W2013798742 @default.
• W2049871389 cites W2017873985 @default.
• W2049871389 cites W2030798165 @default.
• W2049871389 cites W2050801403 @default.
• W2049871389 cites W2054129665 @default.
• W2049871389 cites W2057874628 @default.
• W2049871389 cites W2063544822 @default.
• W2049871389 cites W2070495494 @default.
• W2049871389 cites W2074059194 @default.
• W2049871389 cites W2095433140 @default.
• W2049871389 cites W2106244724 @default.
• W2049871389 cites W2109453374 @default.
• W2049871389 cites W2112943219 @default.
• W2049871389 cites W2114319178 @default.
• W2049871389 cites W2118600639 @default.
• W2049871389 cites W2119044888 @default.
• W2049871389 cites W2120481949 @default.
• W2049871389 cites W2130261432 @default.
• W2049871389 cites W2142066580 @default.
• W2049871389 cites W2147322289 @default.
• W2049871389 cites W2156834167 @default.
• W2049871389 cites W2163194429 @default.
• W2049871389 cites W2170055192 @default.
• W2049871389 cites W4134988 @default.
• W2049871389 doi "https://doi.org/10.1016/j.cyto.2003.07.004" @default.
• W2049871389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14572791" @default.
• W2049871389 hasPublicationYear "2003" @default.
• W2049871389 type Work @default.
• W2049871389 sameAs 2049871389 @default.
• W2049871389 citedByCount "14" @default.
• W2049871389 countsByYear W20498713892015 @default.
• W2049871389 countsByYear W20498713892016 @default.
• W2049871389 countsByYear W20498713892018 @default.
• W2049871389 crossrefType "journal-article" @default.
• W2049871389 hasAuthorship W2049871389A5000012917 @default.
• W2049871389 hasAuthorship W2049871389A5018956979 @default.
• W2049871389 hasAuthorship W2049871389A5059931764 @default.
• W2049871389 hasAuthorship W2049871389A5068002072 @default.
• W2049871389 hasAuthorship W2049871389A5073536820 @default.
• W2049871389 hasAuthorship W2049871389A5081826448 @default.
• W2049871389 hasConcept C104317684 @default.
• W2049871389 hasConcept C111936080 @default.
• W2049871389 hasConcept C147483822 @default.
• W2049871389 hasConcept C150194340 @default.
• W2049871389 hasConcept C153911025 @default.
• W2049871389 hasConcept C167672396 @default.
• W2049871389 hasConcept C170493617 @default.
• W2049871389 hasConcept C185592680 @default.
• W2049871389 hasConcept C19317047 @default.
• W2049871389 hasConcept C195616568 @default.
• W2049871389 hasConcept C203014093 @default.
• W2049871389 hasConcept C2776090121 @default.
• W2049871389 hasConcept C2778938600 @default.
• W2049871389 hasConcept C2779281246 @default.
• W2049871389 hasConcept C2780868878 @default.
• W2049871389 hasConcept C55493867 @default.
• W2049871389 hasConcept C86803240 @default.
• W2049871389 hasConcept C8891405 @default.
• W2049871389 hasConceptScore W2049871389C104317684 @default.
• W2049871389 hasConceptScore W2049871389C111936080 @default.
• W2049871389 hasConceptScore W2049871389C147483822 @default.
• W2049871389 hasConceptScore W2049871389C150194340 @default.
• W2049871389 hasConceptScore W2049871389C153911025 @default.
• W2049871389 hasConceptScore W2049871389C167672396 @default.
• W2049871389 hasConceptScore W2049871389C170493617 @default.
• W2049871389 hasConceptScore W2049871389C185592680 @default.
• W2049871389 hasConceptScore W2049871389C19317047 @default.
• W2049871389 hasConceptScore W2049871389C195616568 @default.
• W2049871389 hasConceptScore W2049871389C203014093 @default.
• W2049871389 hasConceptScore W2049871389C2776090121 @default.
• W2049871389 hasConceptScore W2049871389C2778938600 @default.
• W2049871389 hasConceptScore W2049871389C2779281246 @default.
• W2049871389 hasConceptScore W2049871389C2780868878 @default.
• W2049871389 hasConceptScore W2049871389C55493867 @default.
• W2049871389 hasConceptScore W2049871389C86803240 @default.
• W2049871389 hasConceptScore W2049871389C8891405 @default.
• W2049871389 hasLocation W20498713891 @default.
• W2049871389 hasLocation W20498713892 @default.
• W2049871389 hasOpenAccess W2049871389 @default.

• next