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- W2049877570 abstract "The results in general of the serum treatment of acute poliomyelitis have not been sufficiently consistent to warrant a definite statement as to its value. In the absence of hyperimmune serum, recourse must be had to human convalescent serum, which is at best weak in its antibody content. In a small series, 1 the administration of large doses of convalescent serum a few hours after onset yielded distinctly encouraging results, but it is agreed that the problem has not been solved. Such treatment is beset with obstacles apparently insurmountable, one of the greatest of which is the inaccessibility of the site of injury in poliomyelitic infection. Since the flow of fluid within the nervous tissue itself is probably from the capillaries along the pericapillary, perineuronal and perivascular spaces toward the subarachnoid space, serum injected merely into the subarachnoid sac cannot be expected to reach the inflammatory focus lying deep in" @default.
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- W2049877570 date "1923-08-11" @default.
- W2049877570 modified "2023-09-23" @default.
- W2049877570 title "THE TREATMENT OF ACUTE POLIOMYELITIS" @default.
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- W2049877570 doi "https://doi.org/10.1001/jama.1923.02650060044013" @default.
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